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Table 1 Effects of aspirin and rofecoxib on cellular proliferation, expressed as reduction relative to control

From: Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells

24 h Dose HCA7 HT29 LoVo
aspirin rofecoxib aspirin rofecoxib aspirin rofecoxib
  A 2.0 ± 1.3 1.7 ± 1.4 1.2 ± 0.9 1.3 ± 0.9 1.0 ± 0.3 0.9 ± 0.5
  B 2.9 ± 1.9 1.6 ± 0.6 1.9 ± 1.3 1.1 ± 0.2 1.5 ± 0.6 1.7 ± 1.3
  C 2.4 ± 1.1 2.2 ± 0.8 1.7 ± 0.7 1.8 ± 0.8 1.5 ± 0.6 1.8 ± 1.0
48 h Dose HCA7 HT29 LoVo
aspirin rofecoxib aspirin rofecoxib aspirin rofecoxib
A 2.3 ± 1.2 2.3 ± 1.4 2.0 ± 0.9 1.5 ± 0.6 1.8 ± 0.6 1.4 ± 0.8
B 3.6 ± 1.8 2.5 ± 0.8 2.6 ± 1.7 2.2 ± 1.0 2.7 ± 1.2 2.4 ± 1.3
C 6.0 ± 2.7 3.8 ± 1.4 3.7 ± 1.7 2.4 ± 1.4 2.7 ± 1.2 2.7 ± 0.9
72 h Dose HCA7 HT29 LoVo
aspirin rofecoxib aspirin rofecoxib aspirin rofecoxib
A 4.6 ± 1.7 2.9 ± 1.6 3.4 ± 1.6 3.0 ± 1.8 2.5 ± 1.0 2.4 ± 0.8
B 5.0 ± 1.6 3.5 ± 2.0 4.8 ± 2.3 2.9 ± 1.4 2.8 ± 0.9 2.3 ± 1.0
C 7.7 ± 1.9 4.0 ± 1.6 6.5 ± 2.0 4.1 ± 1.8 5.3 ± 1.8 2.9 ± 1.6
  1. The cells were cultured with 1 μ M rofecoxib, 10 μ M aspirin (dose A); 10 μ M rofecoxib, 100 μ M aspirin (dose B); or 100 μ M rofecoxib, 1,000 μ M aspirin (dose C). Mean and standard deviations are shown.