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Table 1 Effects of aspirin and rofecoxib on cellular proliferation, expressed as reduction relative to control

From: Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells

24 h

Dose

HCA7

HT29

LoVo

aspirin

rofecoxib

aspirin

rofecoxib

aspirin

rofecoxib

 

A

2.0 ± 1.3

1.7 ± 1.4

1.2 ± 0.9

1.3 ± 0.9

1.0 ± 0.3

0.9 ± 0.5

 

B

2.9 ± 1.9

1.6 ± 0.6

1.9 ± 1.3

1.1 ± 0.2

1.5 ± 0.6

1.7 ± 1.3

 

C

2.4 ± 1.1

2.2 ± 0.8

1.7 ± 0.7

1.8 ± 0.8

1.5 ± 0.6

1.8 ± 1.0

48 h

Dose

HCA7

HT29

LoVo

aspirin

rofecoxib

aspirin

rofecoxib

aspirin

rofecoxib

A

2.3 ± 1.2

2.3 ± 1.4

2.0 ± 0.9

1.5 ± 0.6

1.8 ± 0.6

1.4 ± 0.8

B

3.6 ± 1.8

2.5 ± 0.8

2.6 ± 1.7

2.2 ± 1.0

2.7 ± 1.2

2.4 ± 1.3

C

6.0 ± 2.7

3.8 ± 1.4

3.7 ± 1.7

2.4 ± 1.4

2.7 ± 1.2

2.7 ± 0.9

72 h

Dose

HCA7

HT29

LoVo

aspirin

rofecoxib

aspirin

rofecoxib

aspirin

rofecoxib

A

4.6 ± 1.7

2.9 ± 1.6

3.4 ± 1.6

3.0 ± 1.8

2.5 ± 1.0

2.4 ± 0.8

B

5.0 ± 1.6

3.5 ± 2.0

4.8 ± 2.3

2.9 ± 1.4

2.8 ± 0.9

2.3 ± 1.0

C

7.7 ± 1.9

4.0 ± 1.6

6.5 ± 2.0

4.1 ± 1.8

5.3 ± 1.8

2.9 ± 1.6

  1. The cells were cultured with 1 μ M rofecoxib, 10 μ M aspirin (dose A); 10 μ M rofecoxib, 100 μ M aspirin (dose B); or 100 μ M rofecoxib, 1,000 μ M aspirin (dose C). Mean and standard deviations are shown.