Figure 1From: Suboptimal chemotherapy is an adverse prognostic factor in osteosarcomaA Optimal chemotherapy protocol. MTX: methotrexate, DDP: cisplatin, ADM: adriamycin, IFO: ifosfamide. B Age and gender distribution in this cohort. C Proportion of patients receiving suboptimal chemotherapy and optimal chemotherapy. D Initial MRI of a patient with osteosarcoma of the right distal femur. T2-weighted MRI shows altered signal intensity involving the distal metaphysis, growth plate and medial condylar of the right femur with minimal necrosis. E Follow-up after two courses of MTX (8.5 g/m2) and one course of ADM (60 mg/m2) plus DDP (100 mg/m2) demonstrated a positive response to chemotherapy based on the extent of liquefactive necrosis and cystic changes of the soft tissue component despite the absence of a significant reduction in size. MRI magnetic resonance imaging.Back to article page