The bidirectional interation between pancreatic cancer and diabetes

Table 2 Molecular factors involved in progression in PanCa cells related to diabetes

Molecules	Expression levels	Role in PanCa	Refs
IGF-1 and receptor	Increased	Increase the risk and worse survival	[35, 36]
14-amino-acid peptide from S100A8	Increased	Promote the growth of PanCa by activating Akt and NF-κB signaling	[38, 39]
Regenerating gene I alpha protein	Increased	Accelerated cell proliferation	[40]
	Increased	Predictors of poor survival	[41]
	Increased	Contribute to determining diabetes	[42]

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