The detection of hTERC amplification using fluorescence in situ hybridization in the diagnosis and prognosis of cervical intraepithelial neoplasia: a case control study

Table 2 hTERC amplification measured by FISH in exfoliated cervical epithelial cells

Diagnosis	Number	Percentage of positive cell (mean ± SD)	Incidence of positive cases (number positive/total number)
Control group	40	2.4 ± 1.2	0 (0.0)
Study group	151
CIN I	27	9.2 ± 4.6*	44.4% (12 /27)*
CIN II/III	54	16.0 ± 14.4*	85.1% (46/54)*
Carcinoma in situ	17	19.7 ± 13.3*	88.3% (15 /17)*
Invasive Carcinoma	28	47.0 ± 25.2 *	100% (28 /28)*
CIN LEEP post-treatment	11	7.2 ± 2.7*	18.2% (2 /11)
Cervical cancer post-treatment	14	7.1 ± 2.0*	14.3% (2 /14)

FISH, fluorescence in situ hybridization; hTERC, human telomerase mRNA component gene; Number, number of cases; CIN, cervical intraepithelial neoplasia; LEEP, loop electrical excision procedure. *P < 0.05 (compared with the control group).

ISSN: 1477-7819