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Table 2 Association of VEGF-C and VEGF-D expression with P-LVD and I-LVD in breast cancer

From: Peritumoral lymphangiogenesis induced by vascular endothelial growth factor C and D promotes lymph node metastasis in breast cancer patients

  

Cases (N)

I- LVD (mean ± SD)

P-valuea

P-LVD (mean ± SD)

P-valuea

VEGF-C

Negative

11

5.17 ± 2.23

0.96

5.77 ± 2.47

<0.001

 

+

17

5.72 ± 2.02

 

7.74 ± 2.75

 
 

++

26

5.41 ± 1.94

 

9.03 ± 2.88

 
 

+++

12

5.46 ± 2.19

 

10.82 ± 3.12

 
 

++++

7

5.59 ± 2.44

 

11.53 ± 3.26

 

VEGF-D

Negative

18

5.19 ± 2.25

0.88

6.78 ± 2.86

0.005

 

+

20

5.35 ± 1.81

 

8.28 ± 2.61

 
 

++

21

5.53 ± 1.86

 

9.96 ± 3.42

 
 

+++

9

5.81 ± 2.53

 

10.13 ± 3.36

 
 

++++

5

6.16 ± 2.47

 

11.66 ± 3.06

 
  1. I-LVD, intratumoral lymphatic vessel density; P-LVD, peritumoral lymphatic vessel density; VEGF-C/D, vascular endothelial growth factor C /D; aOne-way analysis of variance.