Peritumoral lymphangiogenesis induced by vascular endothelial growth factor C and D promotes lymph node metastasis in breast cancer patients

Table 1 Association of P-LVD and I-LVD with the clinicopathological features of 73 primary breast cancer patients

Factor	Cases (N)	I- LVD (mean ± SD)	P-value	P-LVD (mean ± SD)	P-value
Age
>50	46	5.41 ± 2.09	0.87	8.63 ± 2.92	0.62
≤50	27	5.59 ± 1.99		9.02 ± 3.90
Grade
I / II	55	5.56 ± 2.05	0.58	8.17 ± 2.88	0.47
III	18	5.23 ± 2.02		8.97 ± 3.42
Size
≤3 cm	33	6.12 ± 1.95	0.01	8.24 ± 3.47	0.24
>3 cm	40	4.94 ± 1.98		9.22 ± 3.12
LNM
Negative	34	5.58 ± 1.92	0.74	7.57 ± 3.10	0.005
Positive	39	5.38 ± 2.15		9.82 ± 3.13
LVI
Negative	48	5.57 ± 2.11	0.38	8.04 ± 2.89	0.017
Positive	25	5.29 ± 1.96		10.19 ± 3.61
TNM
I - II	41	5.34 ± 2.05	0.72	7.92 ± 3.44	0.011
III	32	5.62 ± 2.04		9.69 ± 2.91

I-LVD, intratumoral lymphatic vessel density; LNM, lymph node metastasis; LVI, lymphatic vessel invasion; P-LVD, peritumoral lymphatic vessel density; TNM, tumor,node,metastasis stage.

ISSN: 1477-7819