Skip to main content
Figure 4 | World Journal of Surgical Oncology

Figure 4

From: A case of pancreatic neuroendocrine tumor in a patient with neurofibromatosis-1

Figure 4

Microscopic findings of the pancreatic tumor. (a) Tumor cells were composed of ribbons, cords, and solid nests with acinus-like structure (hematoxylin and eosin, magnification 200×). (b) Hyperplasia of islet cells (positive for chromogranin A staining) was frequently found in the non-neoplastic pancreas (chromogranin A staining, magnification 140×). (c,d,e) Expression of chromogranin A, synaptophysin, and CD56 was strongly positive in the tumor cells (c: chromogranin A staining, magnification 400×; d: synaptophysin staining, magnification 400×; e: CD56 staining, magnification 400×). (f/g) Some of tumor cells, particularly in the acinus-like structure, were positive for α1-antichymotrypsin and α1-antitrypsin (f: α1-antichymotrypsin staining, magnification 400×/g: α1-antitrypsin staining, magnification 400×). (h) Expression of neurofibromin was negative in the tumor cells (neurofibromin staining, magnification 400×). (i) Pancreatic islet cells in the non-neoplastic region demonstrated a strongly positive expression of neurofibromin (arrow). Acinar cells and ductal epithelial cells showed negative expression of neurofibromin (neurofibromin staining, magnification 400×).

Back to article page