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Table 3 Literature review

From: Primary malignant non-Hodgkin’s lymphoma of the breast: a study of seven cases and literature review

Authors

Type of study

Number of patients

Histology

Treatment

Follow-up (years)

Survival

Jennings et al. 2007

Database analysis

465

DLBCL, follicular lymphoma, MALT

Mastectomy +/− Chemotherapy +/− Radiotherapy

4

DFS 44.5% overall, no benefit from mastectomy

Ryan et al., 2008

Retrospective

204

DLBCL, MALT

Surgery, chemotherapy, radiotherapy, combined therapy

5.5

Median OS: 8 years, Median PFS: 5.5

Aviles et al., 2005

Prospective

96

DLBCL

RT (45 Gy)

10

CR: 66%, EFS: 50%, OS: 50%

    

CHOP-21 × 6

 

CR: 59%, EFS: 57%, OS: 50%

    

CHOP × 6/RT

 

CR: 88%, EFS: 83%, OS: 76%

Aviles et al., 2007

Prospective Single arm

32

DLBCL

CEOP-R 14 × 6

5.3

CR: 87%, EFS: 63%

Jeanneret- Sozzi et al., 2008

Meta- analysis

84

High-, intermediate-, low-grade lymphomas

Surgery +/− Radiotherapy +/− Chemotherapy

4

OS 5 years 53%, DFS 41% local control rate 87%

  1. DLCL diffuse large cell lymphoma; MALT mucosa-associated lymphoid tissue lymphoma; CR complete remission; CHOP cyclophosphamide, doxorubicin, vincristine, prednisone, CEOP yclophosphamide, epirubicin, vincristine, prednisone; R: rituximab; RT: radiotherapy; OS overall survival; EFS event-free survival; DFS disease-free survival.