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Table 1 Clinical characteristics, treatment and outcomes of literature reports of pancreatic granulocytic sarcomas

From: Isolated granulocytic sarcoma of the pancreas: A tricky diagnostic for primary pancreatic extramedullary acute myeloid leukemia

Author/Year of report

Sex

Age

Concomitant AML

Treatment

Response/Status

King et al./1987

F/36

No

Radiotherapy + CT (Daunorubicin, Cytarabine, Thioguanine)

CR

Moreau et al./1996

M/32

No

Duodenopancreatectomy + CT (Idarubin, Cytarabine)

CR after 2 years follow-up

Marcos et al./1997

F/37

Yes

None

Died after initial MRI

Ravandi - Kashani et al./1999

M/31

Yes

CT (Idarubicin, Cytarabine, All-trans retinoic acid)

CR, (follow-up unknown)

 

F/61

Yes

CT (Idarubicin, Cytarabine, Lisofylline)

Recurrence, died

Servin-Abad et al./2003

M/64

In remission

CT (Unknown regimen)

CR, died of stroke

Breccia et al./2003

F/42

Yes

CT (Cytosine, Arabinoside, Idarubicin)+ BM allogarft

CR at 49 months from graft

Schäfer et al./2008

F/75

Yes

CT (Etoposide, Cytarabine, reduced dose Mitoxantrone)

Recurrence (7 months), died

Rong/2010

M/40

No

Duodenopancreatectomy + CT (Cytarabine based regimen)

CR, (follow-up unknown)

Li et al./2011

F/48

No

Distal pancreatectomy + splenectomy, patient refused adjuvant CT

Recurrence (2 months), died 3 months after surgery

Our study/2011

F/45

No

CT after duodenopancreatectomy

(Cisplatin, Aracytine, Dexamethasone)

Early recurrence, died

 

F/19

No

CT (Aracytine based regimen)

Recurrence (8 months), alive after BM transplantation (22 months follow-up)

  1. AML: Acute Myeloid Leukemia; M: Man; F: Female; CT: Chemotherapy; CR: Complete Response; BM: Bone Marrow