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Table 1 Univariate analysis of the risk factors of death from cancer progression within 1 year after hepatectomy

From: Analysis of the risk factors for early death due to disease recurrence or progression within 1 year after hepatectomy in patients with hepatocellular carcinoma

   Group ED (n = 48) Group NED (n = 465) p -value
Sex Male 40 387  
  Female 8 78 0.9849
Age <60 24 211  
  60 ≤ 24 254 0.5405
HBV + 26 195  
  - 22 270 0.1033
HCV + 14 175  
  - 34 290 0.2469
Albumin <4 33 214  
(g/dl) 4 ≤ 15 251 0.0027
Total bilirubin <0.8 32 283  
(mg/dl) 0.8 ≤ 16 182 0.4314
ICGR15 (%) <15 27 250  
  15 ≤ 21 215 0.7421
Child-Pugh A 42 457  
  B 6 8 <0.0001
AFP (ng/ml) ≤200 15 355  
  200<, ≤1,000 5 37  
  1,000< 28 73 <0.0001
AFP-L3 (%) ≤15 23 334  
  15% < 40< 5 49  
  40< 20 83 0.0002
PIVKA-II (mAU/ml) ≤100 10 258  
  100<, ≤1,000 8 93  
  1,000< 30 114 <0.0001
Liver cirrhosis Present 17 158  
  Absent 31 307 0.8414
Curability R0 R1 40 443  
  R2 8 22 0.0008
Anatomical resection Yes 42 326  
  No 6 139 0.0108
Tumor number 1 16 321  
  2, 3 11 113  
  4 ≤ 21 31 <0.0001
Tumor size ≤2 cm 4 64  
  2-5 cm 6 254  
  5 cm ≤ 38 147 <0.0001
Macroscopic vascular invasion Absent 28 440  
(portal vein, hepatic vein) Present 20 25 <0.0001
Differentiation Well 0 50  
  Moderate 19 308  
  Poor 29 92  
  Necrosis 0 15 <0.0001
Microscopic portal vein invasion vp0 10 369  
  vp1 13 60  
  vp2 7 15  
  vp3 12 15  
  vp4 6 6 <0.0001
Microscopic hepatic vein invasion vv0 28 439  
  vv1 8 12  
  vv2 9 10  
  vv3 3 4 <0.0001
Distant metastasis Absent 43 459  
  Present 5 6 <0.0001
  1. HCC: hepatocellular carcinoma.
  2. NED: alive 1 year after hepatectomy.
  3. ED: death due to HCC recurrence or progression within 1 year after hepatectomy.
  4. HBV: hepatitis B virus s antigen.
  5. HCV: anti-hepatitis C virus antibody.
  6. ICGR15: indocyanin green retention rate at 15 min.
  7. AFP: alpha-fetoprotein.
  8. AFP-L3: Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein.
  9. PIVKA-II: protein induced by vitamin K absence or antagonism factor II.
  10. vp0: no tumor thrombus in the portal vein.
  11. vp1: tumor thrombus distal to the second branches of the portal vein.
  12. vp2: tumor thrombus in the second branches of the portal vein.
  13. vp3: tumor thrombus in the first branch of the portal vein.
  14. vp4: tumor thrombus extension to the trunk or the opposite side branch of the portal vein.
  15. vv0: no tumor thrombus in the hepatic vein.
  16. vv1: tumor thrombus in a branch of the hepatic vein.
  17. vv2: tumor thrombus in the right, middle, or left hepatic vein trunk or the short hepatic vein.
  18. vv3: tumor thrombus to the inferior vena cava.