Analysis of the risk factors for early death due to disease recurrence or progression within 1 year after hepatectomy in patients with hepatocellular carcinoma

Table 1 Univariate analysis of the risk factors of death from cancer progression within 1 year after hepatectomy

		Group ED (n = 48)	Group NED (n = 465)	p -value
Sex	Male	40	387
	Female	8	78	0.9849
Age	<60	24	211
	60 ≤	24	254	0.5405
HBV	+	26	195
	-	22	270	0.1033
HCV	+	14	175
	-	34	290	0.2469
Albumin	<4	33	214
(g/dl)	4 ≤	15	251	0.0027
Total bilirubin	<0.8	32	283
(mg/dl)	0.8 ≤	16	182	0.4314
ICGR15 (%)	<15	27	250
	15 ≤	21	215	0.7421
Child-Pugh	A	42	457
	B	6	8	<0.0001
AFP (ng/ml)	≤200	15	355
	200<, ≤1,000	5	37
	1,000<	28	73	<0.0001
AFP-L3 (%)	≤15	23	334
	15% < 40<	5	49
	40<	20	83	0.0002
PIVKA-II (mAU/ml)	≤100	10	258
	100<, ≤1,000	8	93
	1,000<	30	114	<0.0001
Liver cirrhosis	Present	17	158
	Absent	31	307	0.8414
Curability	R0 R1	40	443
	R2	8	22	0.0008
Anatomical resection	Yes	42	326
	No	6	139	0.0108
Tumor number	1	16	321
	2, 3	11	113
	4 ≤	21	31	<0.0001
Tumor size	≤2 cm	4	64
	2-5 cm	6	254
	5 cm ≤	38	147	<0.0001
Macroscopic vascular invasion	Absent	28	440
(portal vein, hepatic vein)	Present	20	25	<0.0001
Differentiation	Well	0	50
	Moderate	19	308
	Poor	29	92
	Necrosis	0	15	<0.0001
Microscopic portal vein invasion	vp0	10	369
	vp1	13	60
	vp2	7	15
	vp3	12	15
	vp4	6	6	<0.0001
Microscopic hepatic vein invasion	vv0	28	439
	vv1	8	12
	vv2	9	10
	vv3	3	4	<0.0001
Distant metastasis	Absent	43	459
	Present	5	6	<0.0001

HCC: hepatocellular carcinoma.
NED: alive 1 year after hepatectomy.
ED: death due to HCC recurrence or progression within 1 year after hepatectomy.
HBV: hepatitis B virus s antigen.
HCV: anti-hepatitis C virus antibody.
ICGR15: indocyanin green retention rate at 15 min.
AFP: alpha-fetoprotein.
AFP-L3: Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein.
PIVKA-II: protein induced by vitamin K absence or antagonism factor II.
vp0: no tumor thrombus in the portal vein.
vp1: tumor thrombus distal to the second branches of the portal vein.
vp2: tumor thrombus in the second branches of the portal vein.
vp3: tumor thrombus in the first branch of the portal vein.
vp4: tumor thrombus extension to the trunk or the opposite side branch of the portal vein.
vv0: no tumor thrombus in the hepatic vein.
vv1: tumor thrombus in a branch of the hepatic vein.
vv2: tumor thrombus in the right, middle, or left hepatic vein trunk or the short hepatic vein.
vv3: tumor thrombus to the inferior vena cava.

ISSN: 1477-7819