Evaluation of extra capsular lymph node involvement in patients with extra-hepatic bile duct cancer

Table 3 Univariate and multivariate analysis for survival

	Univariate analysis			Multivariate analysis
	Overall survival rate (%)			Relative risk (95% confidence interval)	*P value*
Prognostic factor	3 year	5 year	*P value*	Relative risk (95% confidence interval)
Age
>70	57	37	0.376
≦70	49	43
Gender
Male	52	38	0.359
Female	56	45
Tumor location
Hilar	50	32	0.105
Distal	57	51
pT factor
pT1/2	66	48	0.002	1.15 (0.84-1.57)	0.387
pT3/4	45	34
Lymph node metastasis
Present	26	14	<0.001	1.82 (1.33-2.47)	<0.0001
Absent	68	53
Vascular invasion
Present	30	22	<0.001	1.16 (0.80-1.68)	0.445
Absent	59	44
Perineural invasion
Present	48	33	0.009	1.18 (0.82-1.70)	0.378
Absent	76	64
Histological type
G1	78	63	<0.001	1.27 (0.92-1.76)	0.146
G2/G3/others	43	30
Microscopic margin status
Positive	57	-	0.714
Negative	53	41

Predictive prognostic factors influencing survival: nine independent clinicopathological variables were analyzed as possible prognostic factors in patients with ExHBDCs. On univariate analysis, perineural invasion, vascular invasion, histological grade, and lymph node metastasis were statistically significant factors. A multivariate analysis was also performed using the above four factors.
ExHBDCs: extra-hepatic bile duct cancer; pT: 7th classification of AJCC pathological T factor.

ISSN: 1477-7819