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Table 3 Univariate and multivariate analysis for survival

From: Evaluation of extra capsular lymph node involvement in patients with extra-hepatic bile duct cancer

  Univariate analysis Multivariate analysis
  Overall survival rate (%)   Relative risk (95% confidence interval) P value
Prognostic factor 3 year 5 year P value  
Age
 >70 57 37 0.376   
70 49 43    
Gender      
 Male 52 38 0.359   
 Female 56 45    
Tumor location
 Hilar 50 32 0.105   
 Distal 57 51    
pT factor
 pT1/2 66 48 0.002 1.15 (0.84-1.57) 0.387
 pT3/4 45 34    
Lymph node metastasis
Present 26 14 <0.001 1.82 (1.33-2.47) <0.0001
Absent 68 53    
Vascular invasion
Present 30 22 <0.001 1.16 (0.80-1.68) 0.445
Absent 59 44    
Perineural invasion
Present 48 33 0.009 1.18 (0.82-1.70) 0.378
Absent 76 64    
Histological type
 G1 78 63 <0.001 1.27 (0.92-1.76) 0.146
 G2/G3/others 43 30    
Microscopic margin status
 Positive 57 - 0.714   
 Negative 53 41    
  1. Predictive prognostic factors influencing survival: nine independent clinicopathological variables were analyzed as possible prognostic factors in patients with ExHBDCs. On univariate analysis, perineural invasion, vascular invasion, histological grade, and lymph node metastasis were statistically significant factors. A multivariate analysis was also performed using the above four factors.
  2. ExHBDCs: extra-hepatic bile duct cancer; pT: 7th classification of AJCC pathological T factor.