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Table 3 Description and outcome of patients with High Volume disease based on neoadjuvant chemotherapy (NAC) status

From: Neoadjuvant chemotherapy does not improve survival for patients with high volume colorectal peritoneal metastases undergoing cytoreductive surgery

 

NAC

Non-NAC

p-value

Number [%]

15 [38]

24 [62]

 

Tumour markers

   

CEA (mean [SD])

50 [57]

34 [50]

0.55

CA19.9 (mean [SD])

74 [113]

285 [835]

0.98

CA125 (mean [SD])

77 [95]

123 [160]

0.95

Operative outcome

   

PCI (median [range])

20 [17–29]

20 [17–35]

0.31

CC-0 score (%)

69.7

79.1

0.44

HIPEC (%)

80.0

79.1

0.21

Operating time (mean hours [SD])

9.9 [3.7]

8.0 [3.3]

0.07

ICU LOS (mean days [SD])

12.3 [27.6]

6.2 [10.5]

0.22

Hospital LOS (mean days [SD])

37.0 [41.8]

28.3 [24.3]

0.24

Morbidity~ (%)

33.3

37.5

0.79

Perioperative mortality (n[%])

0 (0)

1 (4.2)

0.89

  1. PCI = Peritoneal Carcinomatosis Index; CC = completeness of cytoreduction; HIPEC = hyperthermic intraperitoneal chemotherapy; ICU = intensive care unit; LOS = length of stay
  2. \(\sim\)Based on Clavien-Dindo Grade III or IV