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Table 2 Patient characteristics between Low Volume and High Volume groups

From: Neoadjuvant chemotherapy does not improve survival for patients with high volume colorectal peritoneal metastases undergoing cytoreductive surgery

 

Low Volume

High Volume

p-value

Number [%]

287 [88]

39 [12]

 

Age (mean years [SD])

56.4 [13.2]

51.4 [16.7]

0.65

Male (%)

39

57

0.39

ASA (median [range])

3 [0–4]

3 [0–4]

0.38

ECOG (median [range])

1 [0–3]

1 [0–2]

0.63

Tumour markers

   

CEA (mean [SD])

31 [93]

79 [131]

0.22

CA19.9 (mean [SD])

28 [159]

35 [51]

< 0.01

CA125 (mean [SD])

42 [109]

177 [637]

0.01

Operative outcome

   

PCI (median [range])

8 [1–16]

20 [17–39]

< 0.01

CC-0 score (%)

95.5

71.8

< 0.01

HIPEC (%)

87.5

89.7

0.11

Operating time (mean hours [SD])

6.6 [2.5]

8.7 [3.5]

< 0.01

ICU LOS (mean days [SD])

2.3 [1.9]

8.4 [18.6]

< 0.01

Hospital LOS (mean days [SD])

21.3 [26.4]

31.5 [31.6]

0.02

Morbidity~ (%)

28.6

35.9

< 0.01

Perioperative mortality (n[%])

2 [0.7]

1 [2.5]

0.96

  1. ASA = American Society of Anaesthesiologist classification; ECOG = Eastern Cooperative Oncology Group status; PCI = Peritoneal Carcinomatosis Index; CC = completeness of cytoreduction; HIPEC = hyperthermic intraperitoneal chemotherapy; ICU = intensive care unit; LOS = length of stay
  2. \(\sim\)Based on Clavien-Dindo Grade III or IV