Table 2 Comparison of perioperative outcomes between patients with unifocal NF-PNETs and multifocal NF-PNETs according to type of surgery
From: Optimal surgical management of unifocal vs. multifocal NF-PNETs: a respective cohort study
Minor resection (Enucleation, DP) | Major resection (PPPD, CP) | Total pancreatectomy | |||||||
|---|---|---|---|---|---|---|---|---|---|
Unifocal | Multifocal | p | Unifocal | Multifocal | p | Unifocal | Multifocal | p | |
(N = 108) | (N = 9) | (N = 54) | (N = 3) | (N = 7) | (N = 6) | ||||
Type of surgery | Enuc: 24 (22.2%) | DP: 9 (100.0%) | 0.247 | PPPD: 46 (85.2%) | PPPD: 2 (66.7%) | 0.966 | - | ||
DP: 84 (77.8%) | CP: 18 (14.8%) | CP:1 (33.3%) | |||||||
MIS | 75 (69.4%) | 7 (77.8%) | 0.884 | 27 (50.0%) | 0 (0.0%) | 0.274 | 3 (42.9%) | 4 (66.7%) | 0.764 |
Male | 57 (52.8%) | 3 (33.3%) | 0.439 | 21 (38.9%) | 2 (66.7%) | 0.726 | 4 (57.1%) | 2 (33.3%) | 0.764 |
Age, mean | 53.7 ± 12.3 | 39.6 ± 15.7 | 0.002 | 57.0 [43.0;65.0] | 47.0 [45.5;48.5] | 0.231 | 51.1 ± 11.8 | 43.5 ± 6.1 | 0.181 |
BMI (kg/m²), mean | 24.4 ± 3.2 | 22.7 ± 3.8 | 0.135 | 23.0 [21.8;25.9] | 24.3 [23.9;25.4] | 0.421 | 22.8 ± 3.4 | 20.6 ± 3.0 | 0.243 |
ASA score | 0.142 | 0.319 | 0.692 | ||||||
27 (25.0%) | 5 (55.6%) | 5 (9.3%) | 1 (33.3%) | 2 (28.6%) | 1 (16.7%) | ||||
60 (55.6%) | 3 (33.3%) | 36 (66.7%) | 2 (66.7%) | 4 (57.1%) | 3 (50.0%) | ||||
21 (19.4%) | 1 (11.1%) | 13 (24.1%) | 0 (0.0%) | 1 (14.3%) | 2 (33.3%) | ||||
Hereditary SD | 3 (2.8%) | 3 (33.3%) | 0.001 | 2 (3.7%) | 0 (0.0%) | > 0.999 | 1 (14.3%) | 6 (100.0%) | 0.011 |
OP time (min), median | 184.5 [141.0;244.5] | 185.0 [169.0;234.0] | 0.79 | 398.5 ± 112.7 | 384.7 ± 136.4 | 0.838 | 407.0 [382.0;504.5] | 432.5 [375.0;526.0] | > 0.999 |
Blood Loss(cc), median | 100.0 [30.0;200.0] | 50.0 [20.0;100.0] | 0.361 | 275.0 [100.0;550.0] | 550.0 [290.0;775.0] | 0.844 | 400.0 [325.0;950.0] | 325.0 [200.0;350.0] | 0.222 |
Transfusion | 4 (3.7%) | 0 (0.0%) | > 0.999 | 6 (11.1%) | 0 (0.0%) | > 0.999 | 3 (42.9%) | 0 (0.0%) | 0.243 |
Postop complication | 41 (38.9%) | 2 (22.2%) | 0.526 | 36 (66.7%) | 2 (66.7%) | > 0.999 | 3 (42.9%) | 4 (66.7%) | 0.764 |
DGE | 0.952 | 0.966 | 0.188 | ||||||
Grade A | 5 (4.6%) | 1 (11.1%) | 8 (14.8%) | 1 (33.3%) | 0 (0.0%) | 2 (33.3%) | |||
Grade B | - | - | - | - | 1 (14.3%) | 0 (0.0%) | |||
POPF | 0.316 | 0.852 | - | - | |||||
Grade A | 36 (33.3%) | 1 (11.1%) | 18 (33.3%) | 1 (33.3%) | - | - | |||
Grade B | 5 (4.6%) | 1 (11.1%) | 5 (9.3%) | 0 (0.0%) | - | - | |||
CCI, median | 0.0 [0.0; 8.7] | 0.0 [0.0; 0.0] | 0.402 | 8.7 [0.0;20.9] | 8.7 [4.3;14.8] | 0.726 | 0.0 [0.0; 8.7] | 8.7 [0.0;20.9] | 0.492 |
clavien dindo (Highest grade) | 0.521 | 0.958 | 0.307 | ||||||
1 | 20 (18.5%) | 1 (11.1%) | 12 (22.2%) | 1 (33.3%) | 2 (28.6%) | 2 (33.3%) | |||
2 | 15 (13.9%) | 0 (0.0%) | 11 (20.4%) | 1 (33.3%) | - | 2 (33.3%) | |||
3a | 6 (5.6%) | 1 (11.1%) | 7 (13.0%) | 0 (0.0%) | - | - | |||
3b | - | - | 3 (5.6%) | 0 (0.0%) | - | - | |||
4a | - | - | 2 (3.7%) | 0 (0.0%) | 1 (14.3%) | - | |||
4b | - | - | - | - | - | - | |||
PostOp LOS (days), median | 9.0 [8.0;13.0] | 10.0 [7.0;14.0] | 0.746 | 14.5 [11.0;27.0] | 20.0 [15.5;25.5] | 0.641 | 20.0 [11.0;28.5] | 14.0 [13.0;15.0] | 0.943 |