Impact of resection margin on outcome in soft-tissue sarcomas of the extremities treated with limb-sparing surgery and postoperative radiotherapy

Table 4 Univariate and multivariable survival analyses for distant recurrence

Variable	Univariate			Multivariable
Variable	HR	95% CI	**P-value**	aHR	95% CI	P-value
Margins (R1 vs R0)	1.07	0.43—2.66	0.882	2.07	0.75—5.74	0.161
Age	1.02	0.99—1.04	0.215
Gender (Female vs Male)	0.65	0.27—1.57	0.340
Size (diameter) (> 5 cm vs ≤ 5 cm)	NA	NA	NA
Location (extremity) (Lower vs Upper)	0.39	0.14—1.06	0.066	0.23	0.07—0.70	0.010
FNCLCC Grade (vs I)
Grade II	3.38	0.72—15.91	0.124	3.55	0.71—17.91	0.124
Grade III	9.48	2.08—43.24	0.004	12.53	2.67—58.88	0.001
Chemotherapy (Yes vs No)	2.25	0.66—7.67	0.194

Abbreviations: R0 microscopically negative margin, R1 microscopically positive margin, FNCLCC the French Federation of Cancer Centers Sarcoma Group, NA no event occurred in a classified subgroup, HR hazard ratio, aHR adjusted hazard ratio, CI confidence interval
P-value < 0.05 is shown in bold
Any variable whose univariate analysis had a p-value < 0.15 was input as a candidate for the multivariable analysis

ISSN: 1477-7819