Impact of resection margin on outcome in soft-tissue sarcomas of the extremities treated with limb-sparing surgery and postoperative radiotherapy

Table 3 Univariate and multivariable survival analyses for local recurrence

Variable	Univariate			Multivariable
Variable	HR	95% CI	P-value	aHR	95% CI	P-value
Margins (R1 vs R0)	0.39	0.11—1.40	0.151	0.59	0.15—2.30	0.444
Age	1.01	0.97—1.05	0.638
Gender (Female vs Male)	0.46	0.12—1.79	0.262
Size (diameter) (> 5 cm vs ≤ 5 cm)	NA	NA	NA
Location (extremity) (Lower vs Upper)	0.46	0.10—2.16	0.322
FNCLCC Grade (vs I)
Grade II	2.24	0.23—21.57	0.484	1.77	0.17—18.62	0.634
Grade III	10.95	1.29—92.63	0.028	8.41	0.90—78.76	0.062
Chemotherapy (Yes vs No)	1.62	0.20—12.93	0.650

Abbreviations: R0 microscopically negative margin, R1 microscopically positive margin, FNCLCC the French Federation of Cancer Centers Sarcoma Group, NA no event occurred in a classified subgroup, HR hazard ratio, aHR adjusted hazard ratio, CI confidence interval
P-value < 0.05 is shown in bold
Any variable whose univariate analysis had a p-value < 0.15 was input as a candidate for the multivariable analysis

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