The therapeutic effect of radiotherapy combined with systemic therapy compared to radiotherapy alone in patients with simple brain metastasis after first-line treatment of limited-stage small cell lung cancer: a retrospective study

Table 3 Univariate and multivariate analyses of variables associated with extracranial progression-free survival

Variable	Univariate analysis			Multivariate analysis
Variable	HR	95% CI	P	HR	95% CI	P
Monotherapy v Combined therapy	0.063	0.404–0.984	0.042	0.617	0.394–0.964	0.034
Gender
Female v Male	1.388	0.818–2.354	0.224
Age, years	0.993	0.972–1.015	0.541
KPS score
90–100 v 70–80	1.015	0.970–1.061	0.532
PCI
No v yes	0.369	0.160–0.849	0.019	0.442	0.188–1.044	0.063
Number of brain metastasis
1–5 v > 5	2.077	1.324–3.258	0.001	1.808	1.140–2.867	0.012

Abbreviations: KPS = karnofsky performance status; PCI = prophylactic cranial irradiation; HR = hazard ratio

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