Octamer-binding transcription factor 4-positive circulating tumor cell predicts worse treatment response and survival in advanced cholangiocarcinoma patients who receive immune checkpoint inhibitors treatment

Table 4 Comparison analyses of treatment response

Items	None CTC (n = 10)	OCT4⁻CTC (n = 12)	OCT4⁺CTC (n = 18)	P value
Treatment response, n (%)				(-)
CR	0 (0.0)	0 (0.0)	0 (0.0)
PR	8 (80.0)	7 (58.3)	4 (22.2)
SD	2 (20.0)	4 (33.4)	10 (55.6)
PD	0 (0.0)	1 (8.3)	4 (22.2)
ORR, n (%)	8 (80.0)	7 (58.3)	4 (22.2)	0.009
DCR, n (%)	10 (100.0)	11 (91.7)	14 (77.8)	0.293

CTC: circulating tumor cell; OCT4: octamer-binding transcription factor 4; CR: complete response; PR: partial response; SD: stable disease; PD: progressive disease; ORR: objective response rate; DCR: disease control rate

ISSN: 1477-7819