STIM1/SOX2 proteins are co-expressed in the tumor and microenvironmental stromal cells of pancreatic ductal adenocarcinoma and ampullary carcinoma

Table 2 Relationship between SOX2 expression and clinicopathological data in the primary PDAC group (No = 48) and AAC (No = 21)

Variables		No	Epithelial SOX2 H-score in PDAC		Test of sig.	No	Epithelial SOX2 H-score in AAC		Test of sig.
			Epithelial SOX2 H-score in PDAC		&		Epithelial SOX2 H-score in AAC		&
			Mean ± SD.	Median	p		Mean ± SD.	Median	p
Age (years)	< 56	22	110.0 ± 116.75	60	U = 283.50	12	108.08 ± 130.47	27.5	U = 47.0
Age (years)	≥ 56	26	100.77 ± 99.69	95	P = 0.958	9	82.22 ± 114.98	10	P = 0.651
Gender	Male	35	105.86 ± 104.46	90	U = 210.50	14	115.86 ± 133.79	35	U = 43.0
Gender	Female	13	102.69 ± 117.13	40	P = 0.690	7	59.29 ± 90.20	10	P = 0.689
Tumor recurrence	Positive	17	108.24 ± 114.47	90	U = 50.0	6	17.50 ± 21.39	10	U = 12.0
Tumor recurrence	Negative	7	55.71 ± 41.17	60	P = 0.576	5	120.80 ± 160.91	10	P = 0.662
Tumor size					r_s= 0.180				r_s= 0.429
Tumor size					P = 0.222				P = 0.052^*
Histologic grade	GI	10	191.00 ± 123.60	240	H = 6.822^*	3	172.67 ± 150.74	240	U = 20.0
	GII	33	78.64 ± 87.65	60		17	89.35 ± 118.17	20
	GIII	5	107.00 ± 117.77	100	P = 0.033^*	1#	0	--	P = 0.616
LVI	Present	15	83.33 ± 95.57	40	U = 206.0	5	115.6 ± 112.77	120	U = 32.50
LVI	Absent	33	114.85 ± 111.46	90	P = 0.351	16	91.19 ± 127.36	10	P = 0.548
Perineural invasion	Present	47	105.53 ± 107.85	90	–	10	146.20 ± 141.9	135	U = 33.50
Perineural invasion	Absent	1^#	80		–	11	52.27 ± 83.05	10	P = 0.132
Pathological stage	Early	29	104.83 ± 113.79	60	U = 275.0	10	65.80 ± 108.62	0.5	U = 35.50
Pathological stage	Late	19	105.26 ± 98.07	100	P = 0.991	11	125.36 ± 131.03	50	P = 0.173
LNs status	Positive	35	95.14 ± 99.64	80	U = 0.199	11	135.82 ± 135.77	120	U = 40.0
LNs status	Negative	13	131.54 ± 124.35	120	P = 0.504	10	54.30 ± 92.69	10	P = 0.314

SOX2: Sex-determining region Y-box2, PDAC: Pancreatic ductal adenocarcinoma, AAC: Ampullary adenocarcinoma, LNs: Lymph nodes, T: Tumor, SD: Standard deviation, H-score: Histo-score, U: Mann Whitney test, H: Kruskal Wallis test, r: Spearman coefficient, p: p-value for comparing between the two categories, *: Statistically significant at P ≤ 0.05. #: Excluded from the comparison due to the small number of cases (n = 1)

ISSN: 1477-7819