STIM1/SOX2 proteins are co-expressed in the tumor and microenvironmental stromal cells of pancreatic ductal adenocarcinoma and ampullary carcinoma

Table 1 Relationship between STIM1 expression and clinicopathological data in the primary PDAC group (No = 48) and AAC (No = 21)

Variables		No	Epithelial STIM1 H-score in PDAC		Test of sig.	No	Epithelial STIM1 H-score in AAC		Test of sig.
			Epithelial STIM1 H-score in PDAC		&		Epithelial STIM1 H-score in AAC		&
			Mean ± SD.	Median	p		Mean ± SD.	Median	p
Age (years)	< 56	22	216.59 ± 77.36	200	U = 261.0	12	188.75 ± 89.85	190	U = 46.500
Age (years)	≥ 56	26	226.54 ± 86.58	255	P = 0.592	9	206.67 ± 71.94	220	P = 0.602
Gender	Male	35	228.0 ± 85.09	260	U = 182.50	14	209.29 ± 83.89	230	U = 35.0
Gender	Female	13	205.77 ± 72.68	200	P = 0.280	7	170.71 ± 74.63	180	P = 0.322
Tumor recurrence	Positive	17	229.12 ± 75.42	215	U = 52.0	6	155.0 ± 60.25	155	U = 5.500
Tumor recurrence	Negative	7	210.0 ± 91.47	200	P = 0.664	5	240.0 ± 78.74	280	P = 0.082
Tumor size					r= -0.144				r_s = -0.032
Tumor size					P = 0.329				P = 0.890
Histologic grade	GI	10	239.50 ± 59.28	237.5	H = 1.722	3	206.67 ± 30.55	200	U = 24.0
	GII	33	211.52 ± 89.34	200	P = 0.423	17	193.24 ± 89.77	200	P = 0.921
	GIII	5	256.0 ± 60.66	300		1^#	220	--
LVI	Present	15	212.67 ± 91.22	200	U = 231.50	5	201.0 ± 101.39	240	U = 36.0
LVI	Absent	33	226.21 ± 78.23	250	P = 0.713	16	195.0 ± 77.72	200	P = 0.780
Pathological stage	Early	29	234.66 ± 72.53	260	U = 227.0	10	185.50 ± 84.93	190	U = 47.50
Pathological stage	Late	19	202.63 ± 92.85	200	P = 0.290	11	206.36 ± 80.41	220	P = 0.605
LNs status	Positive	35	225.29 ± 84.29	250	U = 199.5	10	205.0 ± 80.09	220	U = 47.50
LNs status	Negative	13	213.08 ± 77.07	200	P = 0.501	11	187.0 ± 85.64	200	P = 0.605
Perineural invasion	Present	47	225.0 ± 79.90	250	–	10	201.0 ± 79.37	220	U = 52.0
Perineural invasion	Absent	1^#	80		–	11	192.27 ± 86.47	200	P = 0.863

STIM1: Stromal interaction molecule 1, PDAC: Pancreatic ductal adenocarcinoma, AAC: Ampullary adenocarcinoma, LNs: Lymph nodes, T: Tumor, SD: Standard deviation, H-score: Histo-score, U: Mann Whitney test, H: Kruskal Wallis test, r: Spearman coefficient, p: p-value for comparing between the two categories, *: Statistically significant at P ≤ 0.05
#: Excluded from the comparing due to small number of case (n = 1)

ISSN: 1477-7819