Table 3 Univariate and multivariate analysis for disease-free survival in all patients

Gender

 Female

1

 Male

0.84 (0.63–1.12)

0.242

Age (years)

 < 65

1

 ≥ 65

0.87 (0.66–1.15)

0.329

Tumor length (cm)

 < 3

1

 ≥ 3

0.97 (0.72–1.32)

0.867

Vessel invasion

 Negative

1

 Positive

1.07 (0.72–1.59)

0.726

Perineural invasion

 Negative

1

 Positive

1.24 (0.88–1.73)

0.214

Tumor location

 Upper

1

 Middle

1.11 (0.69–1.76)

0.671

 Lower

0.97 (0.60–1.57)

0.889

Differentiation

 Well

1

1

 Moderate

1.42 (0.92–2.19)

0.114

1.33 (0.86–2.07)

0.205

 Poor

2.22 (1.36–3.64)

0.002

1.88 (1.14–3.11)

0.014

TNM

 I

1

1

 II

1.24 (0.86–1.79)

0.255

1.17 (0.80–1.70)

0.415

 III

1.64 (1.13–2.38)

0.010

1.46 (1.00–2.15)

0.049

Adjuvant treatment

 Yes

1

 No

1.32 (0.96–1.81)

0.089

NPS

 0

1

1

 1

1.40 (0.95–2.06)

0.088

1.30 (0.88–1.92)

0.194

 2

1.90 (1.28–2.82)

0.001

1.59 (1.06–2.38)

0.025

Albumin (g/L)

 < 35

 ≥ 35

0.79 (0.56–1.12)

0.179

PNI

 < 46

1

1

 ≥ 46

0.64 (0.47–0.87)

0.004

0.71 (0.52–0.96)

0.028

COUNT

 Normal/light

1

 Moderate

1.25 (0.86–1.55)

0.072

MAI

 Unbalance

1

1

 Balance

0.65 (0.49–0.87)

0.003

0.70 (0.53–0.93)

0.014