From: Preoperative predictors for non-resectability in perihilar cholangiocarcinoma
 | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Demographics | ||||
 Sex (male = 1) |  | 0.503 |  |  |
 Age (≤ 70 years = 1) |  | 0.223 |  |  |
 BMI (≤ 25 kg/m2 = 1) |  | 0.976 |  |  |
 Bismuth type (I/II = 1) |  | 0.454 |  |  |
 Neoadjuvant therapy (no = 1) |  | 0.425 |  |  |
 Preoperative MRI-Imaging (no = 1) |  | 0.776 |  |  |
 PVE (no = 1) | 2.62 (1.21–5.67) | 0.009 | 4.67 (1.31–16.69) | 0.018 |
 ASA (I/II = 1) |  | 0.341 |  |  |
 Preoperative cholangitis (no = 1) |  | 0,541 |  |  |
 EBD (no = 1) |  | 0.93 |  |  |
 PBD (no = 1) |  | 0.786 |  |  |
 Portal vein infiltration > 180° (no = 1) |  | 0.575 |  |  |
 Arterial infiltration > 180° (no = 1) | 2.29 (1.78–4.48) | 0.017 | 3.24 (1.26–8.31) | 0.015 |
 Lobar atrophy (no = 1) |  | 0.687 |  |  |
 sFLR (≤ 40% = 1) |  | 0.109 |  |  |
Clinical chemistry | ||||
 Albumin (≤ 35 g/l = 1) |  | 0.888 |  |  |
 AST (≤ 50 U/l = 1) |  | 0.239 |  |  |
 ALT (≤ 50 U/l = 1) |  | 0.755 |  |  |
 GGT (≤ 400 U/l = 1) |  | 0.593 |  |  |
 Bilirubin (≤ 1 mg/dl = 1) |  | 0.167 |  |  |
 Alkaline phosphatase (≤ 250 U/l = 1) |  | 0.678 |  |  |
 Platelet count (≤ 300/nl = 1) |  | 0.521 |  |  |
 INR (≤ 1 = 1) |  | 0.698 |  |  |
 Hemoglobin (≤ 12 g/dl = 1) |  | 0.08 |  |  |
 CRP, mg/l (≤ 10 mg/l = 1) |  | 0.404 |  |  |
 CA 19–9 U/ml (≤ 250 U/ml = 1) | 3.91 (1.71–8.93) | 0.001 | 3.2 (1.33–7.69) | 0.009 |