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Table 3 Logistic regression of preoperative parameters for non-resectability due to oncological reasons/liver function

From: Preoperative predictors for non-resectability in perihilar cholangiocarcinoma

 

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

HR (95% CI)

P value

Demographics

 Sex (male = 1)

 

0.503

  

 Age (≤ 70 years = 1)

 

0.223

  

 BMI (≤ 25 kg/m2 = 1)

 

0.976

  

 Bismuth type (I/II = 1)

 

0.454

  

 Neoadjuvant therapy (no = 1)

 

0.425

  

 Preoperative MRI-Imaging (no = 1)

 

0.776

  

 PVE (no = 1)

2.62 (1.21–5.67)

0.009

4.67 (1.31–16.69)

0.018

 ASA (I/II = 1)

 

0.341

  

 Preoperative cholangitis (no = 1)

 

0,541

  

 EBD (no = 1)

 

0.93

  

 PBD (no = 1)

 

0.786

  

 Portal vein infiltration > 180° (no = 1)

 

0.575

  

 Arterial infiltration > 180° (no = 1)

2.29 (1.78–4.48)

0.017

3.24 (1.26–8.31)

0.015

 Lobar atrophy (no = 1)

 

0.687

  

 sFLR (≤ 40% = 1)

 

0.109

  

Clinical chemistry

 Albumin (≤ 35 g/l = 1)

 

0.888

  

 AST (≤ 50 U/l = 1)

 

0.239

  

 ALT (≤ 50 U/l = 1)

 

0.755

  

 GGT (≤ 400 U/l = 1)

 

0.593

  

 Bilirubin (≤ 1 mg/dl = 1)

 

0.167

  

 Alkaline phosphatase (≤ 250 U/l = 1)

 

0.678

  

 Platelet count (≤ 300/nl = 1)

 

0.521

  

 INR (≤ 1 = 1)

 

0.698

  

 Hemoglobin (≤ 12 g/dl = 1)

 

0.08

  

 CRP, mg/l (≤ 10 mg/l = 1)

 

0.404

  

 CA 19–9 U/ml (≤ 250 U/ml = 1)

3.91 (1.71–8.93)

0.001

3.2 (1.33–7.69)

0.009

  1. Various parameters are associated with non-resectability. Statistically significant p values are presented in brackets
  2. ALT Alanine aminotransferase, ASA American Society of Anesthesiologists classification, AST Aspartate aminotransferase, BMI Body mass index, CRP C-reactive protein, EBD Endoscopic biliary drainage, GGT Gamma-glutamyltransferase, INR International normalized ratio, PBD Percutaneous biliary drainage, PVE Portal vein embolization