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Table 2 Logistic regression of preoperative parameters for non-resectability due to technical reasons

From: Preoperative predictors for non-resectability in perihilar cholangiocarcinoma

 

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

HR (95% CI)

P value

Demographics

 Sex (male = 1)

 

0.1

  

 Age (≤ 70 years = 1)

2.43 (1.15–5.16)

0.019

3.76 (1.56–9.08)

0.003

 BMI (≤ 25 kg/m2 = 1)

 

0.561

  

 Bismuth type (I/II = 1)

 

0.087

  

 Neoadjuvant therapy (no = 1)

 

0.636

  

 Preoperative MR-Imaging (no = 1)

 

0.666

  

 PVE (no = 1)

5.48 (1.62–18.57)

0.001

5.73 (1.61–20.38)

0.007

 ASA (I/II = 1)

 

0.401

  

 Preoperative cholangitis (no = 1)

 

0.84

  

 EBD (no = 1)

 

0.909

  

 PBD (no = 1)

 

0.315

  

 Portal vein infiltration > 180° (no = 1)

 

0.139

  

 Arterial infiltration > 180° (no = 1)

5.2 (2.41–11.22)

 < 0.001

8.05 (3.32–19.53)

 < 0.001

 Lobar atrophy (no = 1)

 

0.765

  

 sFLR (≤ 40% = 1)

 

0.468

  

Clinical chemistry

 Albumin (≤ 35 g/l = 1)

 

0.353

  

 AST (≤ 50 U/l = 1)

 

0.649

  

 ALT (≤ 50 U/l = 1)

 

0.315

  

 GGT (≤ 400 U/l = 1)

 

0.263

  

 Bilirubin (≤ 1 mg/dl = 1)

 

0.921

  

 Alkaline phosphatase (≤ 250 U/l = 1)

 

0.439

  

 Platelet count (≤ 300/nl = 1)

 

0.462

  

 INR (≤ 1 = 1)

 

0.364

  

 Hemoglobin (≤ 12 g/dl = 1)

 

0.819

  

 CRP, mg/l (≤ 10 mg/l = 1)

 

0.694

  

 CA 19–9, U/ml (≤ 250 U/ml = 1)

 

0.673

  
  1. Various parameters are associated with non-resectability. Statistically significant p values are presented in brackets
  2. ALT Alanine aminotransferase, ASA American Society of Anesthesiologists classification, AST Aspartate aminotransferase, BMI Body mass index, CRP C-reactive protein, EBD Endoscopic biliary drainage, GGT Gamma-glutamyltransferase, INR International normalized ratio, PBD Percutaneous biliary drainage, PVE Portal vein embolization