From: Preoperative predictors for non-resectability in perihilar cholangiocarcinoma
 | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Demographics | ||||
 Sex (male = 1) |  | 0.1 |  |  |
 Age (≤ 70 years = 1) | 2.43 (1.15–5.16) | 0.019 | 3.76 (1.56–9.08) | 0.003 |
 BMI (≤ 25 kg/m2 = 1) |  | 0.561 |  |  |
 Bismuth type (I/II = 1) |  | 0.087 |  |  |
 Neoadjuvant therapy (no = 1) |  | 0.636 |  |  |
 Preoperative MR-Imaging (no = 1) |  | 0.666 |  |  |
 PVE (no = 1) | 5.48 (1.62–18.57) | 0.001 | 5.73 (1.61–20.38) | 0.007 |
 ASA (I/II = 1) |  | 0.401 |  |  |
 Preoperative cholangitis (no = 1) |  | 0.84 |  |  |
 EBD (no = 1) |  | 0.909 |  |  |
 PBD (no = 1) |  | 0.315 |  |  |
 Portal vein infiltration > 180° (no = 1) |  | 0.139 |  |  |
 Arterial infiltration > 180° (no = 1) | 5.2 (2.41–11.22) |  < 0.001 | 8.05 (3.32–19.53) |  < 0.001 |
 Lobar atrophy (no = 1) |  | 0.765 |  |  |
 sFLR (≤ 40% = 1) |  | 0.468 |  |  |
Clinical chemistry | ||||
 Albumin (≤ 35 g/l = 1) |  | 0.353 |  |  |
 AST (≤ 50 U/l = 1) |  | 0.649 |  |  |
 ALT (≤ 50 U/l = 1) |  | 0.315 |  |  |
 GGT (≤ 400 U/l = 1) |  | 0.263 |  |  |
 Bilirubin (≤ 1 mg/dl = 1) |  | 0.921 |  |  |
 Alkaline phosphatase (≤ 250 U/l = 1) |  | 0.439 |  |  |
 Platelet count (≤ 300/nl = 1) |  | 0.462 |  |  |
 INR (≤ 1 = 1) |  | 0.364 |  |  |
 Hemoglobin (≤ 12 g/dl = 1) |  | 0.819 |  |  |
 CRP, mg/l (≤ 10 mg/l = 1) |  | 0.694 |  |  |
 CA 19–9, U/ml (≤ 250 U/ml = 1) |  | 0.673 |  |  |