Table 5 Cox multivariate regression analysis of factors affecting postoperative recurrence of HCCA

Gender, male vs. female

0.920

0.878

Age, years (< 65 vs. ≥ 65)

0.970

0.953

Preoperative biliary drainage, yes vs. no

2.050

0.217

CA-199, U/mL

1.000

0.679

CEA, μg/L

1.020

0.132

Radical resection, yes vs. no

0.640

0.764

Operation time, min

1.000

0.762

Tumor size, < 3 cm vs. ≥ 3 cm

1.940

0.387

Surgical margin, R0/ R1/ R2

2.420

0.223

Bismuth type, I/II/IIIa/IIIb/IV

1.410

0.463

Pathological differentiation types,

highly/moderately/poorly

0.620

0.325

Perineuronal invasion, yes vs. no

5.180

0.030*

Intravascular tumor thrombus, yes vs. no

2.060

0.221

Lymph node metastasis, yes vs. no

2.100

0.206

Postoperative complications, yes vs. no

2.280

0.303

Postoperative adjuvant therapy, yes vs. no

1.270

0.710

Treatment (LS vs. OS)

0.920

0.896