Table 4 Cox multivariate regression analysis of factors affecting overall survival in HCCA

Gender, female vs. male

0.940

0.867

Age, years (< 65 vs. ≥ 65)

0.380

0.036*

ECOG-PS, 0~1 vs. 2

1.920

0.202

Child-Pugh classification, B vs. C

1.610

0.268

Comorbidity, yes vs. no

0.950

0.912

Preoperative biliary drainage, yes vs. no

2.810

0.026*

CA-199, U/mL

1.000

0.895

Radical resection, yes vs. no

0.080

0.024*

Operation time, min

1.000

0.295

Hilar blockade, yes vs. no

2.170

0.081

Tumor size, < 3 cm vs. ≥ 3 cm

0.970

0.948

Surgical margin, R0/R1/R2

0.970

0.940

Bismuth type, I/II/IIIa/IIIb/IV

1.380

0.309

Pathological differentiation types, highly/moderately/poorly

0.770

0.409

Perineuronal invasion, yes vs. no

1.450

0.423

Lymph node metastasis, yes vs. no

2.140

0.053

Postoperative complications, yes vs. no

1.740

0.330

Postoperative adjuvant therapy, yes vs. no

0.380

0.040*

Treatment (LS vs. OS)

1.290

0.570