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Table 1 Demographic and baseline characteristics of patients in the LS and OS groups

From: Survival analysis of laparoscopic surgery and open surgery for hilar cholangiocarcinoma: a retrospective cohort study

Characteristic

LS group (n = 40)

OS group (n = 28)

p-value

Gender, n (%)

  Male

22 (55.0)

21 (75.0)

0.127

   Female

18 (45.0)

7 (25.0)

 

Age, years, median (IQR)

63 (53.5–68)

64.5 (57.0–69.75)

0.403

BMI, kg/m2

22.5 (20.76–23.60)

21.9 (19.76–24.75)

0.596

ECOG-PS, n (%)

  0

9 (22.5)

8 (28.57)

0.393

   1

25 (62.5)

13 (46.43)

 

  2

6 (15.0)

7 (25.0)

 

ASA score, n (%)

  I

13 (32.5)

1 (3.57)

0.002*

  II

19 (47.5)

12 (42.86)

 

  III

8 (20.0)

15 (53.57)

 

Child-Pugh classification

  B

32 (80.0)

15 (53.57)

0.032*

  C

8 (20.0)

13 (46.43)

 

Comorbidity, n (%)

  Diabetes

2 (5.0)

3 (10.7)

0.396

  Hypertension

8 (20.0)

2 (7.14)

0.179

  Cardiac insufficiency

3 (7.5)

2 (7.14)

> 0.999

  Pulmonary insufficiency

1 (2.5)

2 (7.14)

0.564

  Cerebrovascular disease

0

1 (3.57)

0.412

  Viral hepatitis

5 (12.5)

1 (3.57)

0.389

  Cirrhosis

3 (7.50)

2 (7.14)

> 0.999

  Gallstones

5 (12.5)

3 (10.71)

> 0.999

  Cholecystitis

3 (7.50)

7 (25.0)

0.079

  Previous abdominal surgery, n (%)

6 (15.0)

5 (17.86)

0.751

Preoperative biliary drainage, n (%)

  PTCD

22 (55.0)

12 (42.86)

0.460

  ERCP

0(0)

1 (3.57)

0.412

Preoperative liver function

  ALT, U/L

64.5 (35.75–127.5)

83.7 (50–134.75)

0.419

  AST, U/L

60 (41–101.5)

65.7 (45.85–107.25)

0.414

  GGT, U/L

205.85 (114.5–652)

548.1 (307.25–854.5)

0.006*

  DBIL, μmol/L

91.3 ± 68.34

97.39 ± 61.12

0.702

  TBIL, μmol/L

143.1 ± 100.39

148.2 ± 83.37

0.826

  ALB, g/L

38.95 (34.725–42.2)

38.65 (34.0–41.0)

0.529

  ALP, U/L

279 (212–597.75)

416.8 (232.8–637.25)

0.124

Preoperative coagulation function

  APTT, s

34.52 ± 4.89

35.46 ± 5.33

0.453

  FIB, g/L

4.22 (3.65–4.89)

4.56 (3.62–5.53)

0.246

  INR

0.97 (0.91–1.0325)

0.935 (0.9025–1.015)

0.685

  PT, s

12.55 (11.625–13.1)

12.5 (11.7–13.5)

0.774

Preoperative tumor markers

  CA-199, U/mL

270.8 (36.10–2581.14)

330.8 (76.46–1385.5)

0.975

  CEA, μg/L

2.235 (0.925–5.808)

2.140 (1.013–4.488)

0.627

  AFP, μg/L

2.55 (0.90–6.30)

2.16 (1.62–3.865)

0.831

  1. LS, laparoscopic surgery; OS, open surgery; IQR, interquartile range; BMI, body mass index; ECOG-PS, Eastern Cooperative Oncology Group performance status; ASA, American Society of Anesthesiologists; PTCD, percutaneous transhepatic cholangial drainage; ERCP, endoscopic retrograde cholangiopancreatography; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transpeptidase; DBIL, direct bilirubin; TBIL, total bilirubin; ALB, albumin; ALP, alkaline phosphatase; APTT, activated partial thromboplastin time; FIB, fibrinogen; INR, international normalized ratio; PT, prothrombin time; CA-199, cancer antigen 19-9; CEA, carcinoembryonic antigen; AFP, alpha-fetoprotein. “*”Indicates a statistically significant difference (P < 0.05)