Table 3 The pooled results of the multivariate analysis of OS and DFS
Clinical endpoints | Prognostic factors | No. of study | Sample | HR (95% CI) | p-value | I2 (%) |
|---|---|---|---|---|---|---|
OS | Gender (female vs. male) | 3 | 176 | 0.80 (0.32, 1.96) | 0.618 | 0.0 |
Age (older vs. younger) | 6 | 497 | 1.06 (0.99, 1.14) | 0.090 | 66.6 | |
TNM stage (III-IV vs. I-II) | / | / | / | / | / | |
Smoking status (yes vs. no) | 4 | 385 | 4.71 (1.52, 14.58) | 0.007 | 56.8 | |
Tumor size (bigger vs. smaller) | 5 | 667 | 1.27 (1.07, 1.50) | 0.006 | 67.9 | |
Metastasis (no vs. yes) | Â | Â | Â | Â | Â | |
Lymph node metastasis | 3 | 338 | 0.14 (0.07, 0.28) |  < 0.001 | 0.0 | |
Pleural invasion | / | / | / | / | / | |
Pathological features | Â | Â | Â | Â | Â | |
STAS (+ vs. −) | 2 | 240 | 6.10 (2.17, 17.12) | 0.001 | 0.0 | |
Pathological grade (higher vs. lower) | 2 | 191 | 3.44 (0.80, 14.75) | 0.096 | 62.1 | |
Gene mutation (positive vs. negative) | Â | Â | Â | Â | Â | |
EGFR mutation | / | / | / | / | / | |
ALK mutation | 2 | 129 | 0.44 (0.04, 4.49) | 0.492 | 76.4 | |
CT manifestations | Â | Â | Â | Â | Â | |
CT morphology (consolidative vs. nodular type) | 3 | 321 | 3.44 (0.78, 15.17) | 0.102 | 62.9 | |
Pneumonia type (pneumonia vs. solitary) | 2 | 119 | 3.39 (1.19, 9.62) | 0.022 | 3.4 | |
Well defined heterogeneous GGO (+ vs. −) | 2 | 240 | 1.20 (0.44, 3.25) | 0.722 | 0.0 | |
Spiculated margin (+ vs. −) | / | / | / | / | / | |
Lobulated margin (+ vs. −) | / | / | / | / | / | |
Air bronchogram (+ vs. −) | / | / | / | / | / | |
DFS | Gender (female vs. male) | / | / | / | / | / |
Age (older vs. younger) | 3 | 300 | 1.02 (0.99, 1.06) | 0.232 | 37.3 | |
TNM stage (III-IV vs. I-II) | / | / | / | / | / | |
Smoking status (yes vs. no) | 2 | 179 | 1.83 (0.84, 4.01) | 0.130 | 0.0 | |
Tumor size (bigger vs. smaller) | 3 | 251 | 2.22 (1.01, 4.90) | 0.047 | 72.1 | |
Metastasis (no vs. yes) | Â | Â | Â | Â | Â | |
Lymph node metastasis | 2 | 219 | 0.18 (0.09, 0.35) |  < 0.001 | 0.0 | |
Pleural invasion | / | / | / | / | / | |
Pathological features | Â | Â | Â | Â | Â | |
STAS (+ vs. −) | / | / | / | / | / | |
Pathological grade (higher vs. lower) | 2 | 123 | 8.94 (3.10, 25.80) |  < 0.001 | 0.0 | |
Gene mutation (positive vs. negative) | Â | Â | Â | Â | Â | |
EGFR mutation | / | / | / | / | / | |
ALK mutation | / | / | / | / | / | |
CT manifestations | Â | Â | Â | Â | Â | |
CT morphology (consolidative vs. nodular type) | 2 | 202 | 1.32 (0.15, 11.74) | 0.804 | 79.3 | |
Pneumonia type (pneumonia vs. solitary) | 2 | 389 | 2.90 (1.55, 5.42) | 0.001 | 19.3 | |
Well defined heterogeneous GGO (+ vs. −) | / | / | / | / | / | |
Spiculated margin (+ vs. −) | / | / | / | / | / | |
Lobulated margin (+ vs. −) | / | / | / | / | / | |
Air bronchogram (+ vs. −) | / | / | / | / | / |