Table 2 The pooled results of the univariate analysis of OS and DFS

OS

Gender (female vs. male)

7

711

0.53 (0.40, 0.71)

0.001

0.0

Age (older vs. younger)

8

830

1.10 (0.99, 1.22)

0.087

74.7

TNM stage (III-IV vs. I-II)

2

98

3.62 (1.85, 7.08)

 < 0.001

30.9

Smoking status (yes vs. no)

6

801

1.82 (1.34, 2.47)

 < 0.001

0.1

Tumor size (bigger vs. smaller)

4

586

1.46 (1.10, 1.93)

0.008

82.0

Metastasis (no vs. yes)

Lymph node metastasis

6

780

0.26 (0.19, 0.36)

 < 0.001

24.7

Pleural invasion

2

415

0.39 (0.23, 0.66)

 < 0.001

0.0

Pathological features

STAS (+ vs. −)

3

339

2.23 (1.16, 4.26)

0.015

0.0

Pathological grade (higher vs. lower)

2

191

2.77 (0.91, 8.41)

0.072

53.8

Gene mutation (positive vs. negative)

EGFR mutation

3

152

0.70 (0.35, 1.41)

0.322

0.0

ALK mutation

2

129

0.62 (0.13, 3.03)

0.553

60.0

CT manifestations

CT morphology (consolidative vs. nodular type)

2

240

3.11 (1.90, 5.11)

 < 0.001

0.0

Pneumonia type (pneumonia vs. solitary)

3

436

5.81 (3.68, 9.19)

 < 0.001

0.0

Well-defined heterogeneous GGO (+ vs. −)

2

240

2.31 (1.27, 4.19)

0.006

0.0

Spiculated margin (+ vs. −)

2

240

0.70 (0.54, 0.92)

0.012

0.0

Lobulated margin (+ vs. −)

2

240

1.09 (0.66, 1.80)

0.722

0.0

Air bronchogram (+ vs. −)

3

557

1.40 (0.71, 2.78)

0.336

64.8

DFS

Gender (female vs. male)

3

536

0.67 (0.49, 0.90)

0.009

26.2

Age (older vs. younger)

3

536

1.04 (1.01, 1.07)

0.013

0.0

TNM stage (III-IV vs. I-II)

/

/

/

/

/

Smoking status (yes vs. no)

3

536

1.41 (1.03, 1.93)

0.032

0.0

Tumor size (bigger vs. smaller)

3

487

2.50 (0.91, 6.87)

0.076

90.5

Metastasis (no vs. yes)

Lymph node metastasis

3

536

0.26 (0.19, 0.35)

 < 0.001

33.6

Pleural invasion

2

415

0.55 (0.25, 1.22)

0.144

55.6

Pathological features

STAS (+ vs. −)

/

/

/

/

/

Pathological grade (higher vs. lower)

2

123

4.46 (1.92, 10.38)

0.001

0.0

Gene mutation (positive vs. negative)

EGFR mutation

2

172

0.52 (0.09, 2.91)

0.459

72.5

ALK mutation

/

/

/

/

/

CT manifestations

CT morphology (consolidative vs. nodular type)

/

/

/

/

/

Pneumonia type (pneumonia vs. solitary)

2

389

5.17 (3.31, 8.08)

 < 0.001

37.4

Well-defined heterogeneous GGO (+ vs. −)

/

/

/

/

/

Spiculated margin (+ vs. −)

/

/

/

/

/

Lobulated margin (+ vs. −)

/

/

/

/

/

Air bronchogram (+ vs. −)

2

438

1.77 (0.55, 5.67)

0.340

85.1