Fig. 5

Immune infiltration analysis of TFP tumors. A Identifying the relative infiltration of immune cell populations for 435 PC of reference samples in TCGA using ssGSEA method. The relative infiltration of each cell type is normalized into a z-score. B Relationship between infiltration of cell types executing anti-tumor immunity and cell types executing pro-tumor, immune suppressive functions. R coefficient and p value were calculated by Pearson’s correlation method. C Abundance of M1 and M2 immune cells between the TFP and TFN tumors from the TCGA dataset. D Immune cytolytic (CYT) score across 435 PC samples derived from TCGA sequencing data stratified by TFP (red) and TFN (blue) status. Immune score and stromal score computed by E estimated method and F xCell method between the TFP and TFN samples. p values in the heatmap and box plot were determined by one-sided Wilcoxon test. *p < 0.05, **p < 0.01, ***p < 0.001