Table 3 Univariate and multivariate analyses results for OS in postoperative LSCC patients

Age at diagnosis (years)

 < 70

Reference

Reference

 ≥ 70

2.351 (1.452–3.805)

0.001***

2.334 (1.382–3.976)

0.002**

Gender

 Male

Reference

 Female

0.738 (0.456–1.197)

0.218

Primary site

 Upper

Reference

 Lower

1.566 (0.676–3.626)

0.295

Grade

0.177

 Well differentiate

Reference

 Moderate differentiate

1.356 (0.760–2.419)

0.302

 Poor differentiate

1.742 (0.969–3.133)

0.064

Perineural invasion

 No

Reference

 Yes

1.758 (0.802–3.856)

0.159

AJCC stage

 I

Reference

Reference

 II

1.942 (0.817–4.615)

0.133

1.240 (0.507–3.036)

0.637

 III

3.497 (1.554–7.868)

0.002**

2.150 (0.888–5.207)

0.090

 IV

5.963 (2.458–14.464)

< 0.001***

3.841 (1.516–9.734)

0.005**

BMI

0.976 (0.918–1.037)

0.428

HGB

0.994 (0.983–1.005)

0.283

ECOG PS

 0–1

Reference

 2

0.981 (0.559–1.722)

0.946

GPS

 0

Reference

Reference

 1

1.539 (0.824–2.874)

0.176

1.986 (1.020–3.864)

0.043*

 2

2.892 (1.533–5.453)

0.001***

2.127 (1.070–4.229)

0.031*

SII

1.000 (1.000–1.001)

< 0.001***

1.000 (1.000–1.001)

0.003**

PNI

0.985 (0.975–0.995)

0.004**

0.992 (0.980–1.003)

0.146

PLR

1.002 (0.999–1.004)

0.167

NLR

1.139 (0.920–1.410)

0.231

ACCI

 < 5

Reference

Reference

 ≥ 5

2.597 (1.587–4.252)

< 0.001***

2.402 (1.403–4.111)

0.001***

Vascular invasion

 No

Reference

Reference

 Yes

2.390 (1.342–4.257)

0.003**

0.953 (0.489–1.858)

0.887

Surgical margin (mm)

 < 5

Reference

Reference

 ≥ 5

0.477 (0.272–0.837)

0.010**

0.521 (0.276–0.984)

0.045

ENE

 Negative

Reference

Reference

 Positive

2.703 (1.495–4.889)

0.001***

1.854 (0.936–3.674)

0.077

Multiple primary tumors

 No

Reference

 Yes

1.990 (0.856–4.627)

0.110

Adjuvant chemotherapy

 No

Reference

 Yes

0.824 (0.497–1.364)

0.452

Adjuvant radiotherapy

 No

Reference

 Yes

0.808 (0.500–1.306)

0.385