Table 2 Univariate and multivariate analyses results for PFS in postoperative LSCC patients

Age at diagnosis (years)

 < 70

Reference

Reference

 ≥ 70

2.294 (1.522–3.458)

< 0.001***

2.986 (1.780–5.009)

0.001***

Gender

 Male

Reference

 Female

0.862 (0.553–1.343)

0.511

Primary site

 Upper

Reference

 Lower

1.051 (0.541–2.041)

0.884

Grade

0.081

 Well differentiate

Reference

 Moderate differentiate

1.541 (0.908–2.616)

0.109

1.895 (1.078–3.332)

0.026*

 Poor differentiate

1.819 (1.053–3.141)

0.032*

2.688 (1.447–4.995)

0.002**

Perineural invasion

 No

Reference

 Yes

1.641 (0.789–3.413)

0.185

AJCC stage

 I

Reference

Reference

 II

1.824 (0.843–3.946)

0.127

1.219 (0.548–2.714)

0.628

 III

2.855 (1.369–5.957)

0.005**

2.196 (1.001–4.819)

0.050

 IV

5.393 (2.443–11.906)

< 0.001***

3.814 (1.682–8.651)

0.001***

BMI

0.962 (0.909–1.019)

0.189

Hemoglobin

0.994 (0.983–1.004)

0.207

ECOG PS

 0–1

Reference

 2

1.066 (0.641–1.771)

0.806

GPS

 0

Reference

Reference

 1

1.536 (0.874–2.700)

0.136

1.823 (0.998–3.332)

0.051

 2

2.302 (1.242–4.265)

0.008**

1.654 (0.876–3.123)

0.121

SII

1.000 (1.000–1.000)

0.003**

1.000 (1.000–1.001)

0.013*

PNI

0.986 (0.976–0.995)

0.003**

0.989 (0.979–1.000)

0.047

PLR

1.001 (0.998–1.003)

0.518

NLR

1.081 (0.890–1.312)

0.433

ACCI

 < 5

Reference

Reference

 ≥ 5

2.108 (1.343–3.308)

0.001***

1.731 (1.075–2.788)

0.024*

Vascular invasion

 No

Reference

Reference

 Yes

2.233 (1.268–3.934)

0.005**

0.918 (0.473–1.782)

0.800

Surgical margin (mm)

 < 5

Reference

Reference

 ≥ 5

0.530 (0.306–0.919)

0.024*

0.523 (0.282–0.970)

0.040*

ENE

 Negative

Reference

Reference

 Positive

2.312 (1.291–4.139)

0.005**

1.055 (0.533–2.088)

0.878

Multiple primary tumors

 No

Reference

 Yes

2.125 (1.017–4.440)

0.045

Adjuvant chemotherapy

 No

Reference

 Yes

0.704 (0.438–1.132)

0.147

Adjuvant radiotherapy

 No

Reference

 Yes

0.752 (0.484–1.170)

0.205