Table 2 Subgroup analysis for overall survival

Measurement method

 SMI

12

2952

1.49

1.36–1.63

 < 0.00001

21%

 PMI

3

1550

1.62

1.38–1.91

 < 0.00001

0%

Region of studies

 Asia

12

3499

1.54

1.41–1.68

 < 0.00001

31%

 Non-Asia

3

1003

1.51

1.22–1.86

0.0001

0%

Definition of cut-off values

 ROC curves

5

877

1.69

1.48–1.94

 < 0.00001

0%

 Lowest quantile

5

2159

1.45

1.27–1.65

 < 0.00001

34%

 Prado’s definition

4

1119

1.44

1.18–1.76

0.0003

22%