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Table 5 Univariate analyses of the PFS in EOC compared with clinicopathological and genomic characteristics and CD47

From: CD47—a novel prognostic predicator in epithelial ovarian cancer and correlations with clinicopathological and gene mutation features

Variables

p-value

Hazard ratio (95% CI)

CD47 (high vs. low)

0.002

4.449 (1.698–11.924)

PD-L1 (positive vs. negative)

0.105

0.445 (0.167–1.183)

FIGO stage (I + II vs. III + IV)

0.013

3.863 (1.333–11.194)

Preoperative serum CA125 (≥ 500 U/mL vs. < 500 U/mL)

0.015

2.573 (1.198–5.525)

Preoperative serum HE4 (increased vs. normal)

0.466

1.451 (0.533–3.949)

Multidisciplinary surgeries (yes vs.no)

0.006

3.173 (1.386–7.261)

Presence of ascites (yes vs.no)

0.135

2.242 (0.779–6.453)

Volume of ascites (≥ 1000 ml vs. < 1000 ml)

0.037

2.201 (1.049–4.620)

Lymph-node metastasis (positive vs. negative)

0.005

3.110 (1.404–6.890)

Ki-67 index (positive vs. negative)

0.129

1.800 (0.843–3.845)

Residual disease (optimal vs. suboptimal)

0.544

1.302 (0.555–3.057)

BRCA mutation status (pathogenic mutation vs. wild type)

0.091

0.434 (0.165–1.142)

HRD statusa (positive vs. negative)

0.074

0.429 (0.169–1.087)

TP53 mutation status (pathogenic mutation vs. wild type)

0.877

1.065 (0.476–2.383)

  1. aK-M curves showed similar results to BRCA mutation, and HRD status was not included in subsequent multivariate analysis due to the complete BRCA mutation was contained in HRD status (Supplementary Fig. 3)