Table 2 Univariate and multivariate analysis of prognostic factors for OS and DFS in low-risk stage III CC patients from our institution

Variable

OS

Univariate analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

Sex

(Woman vs. Man)

0.461 (0.262–0.812)

0.007

0.527 (0.297–0.933)

0.028

Age

(≥ 60 vs. < 60)

2.352 (1.420–3.898)

0.001

2.668 (1.591–4.474)

P < 0.001

Laparoscopic surgery

(Yes vs. No)

0.499 (0.284–0.879)

0.016

0.528 (0.294–0.948)

0.033

Tumor location

(Left vs. Right)

0.706 (0.420–1.188)

0.190

-

-

No. LNs harvested

(< 12 vs. ≥ 12)

0.678 (0.345–1.332)

0.259

-

-

Histologic grade

(Poorly vs. Well/moderately)

1.583 (0.934–2.681)

0.088

1.723 (1.005–2.951)

0.048

Histological type

(Mucinous or Signet ring cell vs. Adenocarcinoma)

1.235 (0.660–2.312)

0.509

-

-

Lymphovascular Invasion

(Yes vs. No)

1.537 (0.821–2.879)

0.179

-

-

Perineural invasion

(Yes vs. No)

2.169 (1.288–3.652)

0.004

2.273 (1.328–3.888)

0.003

CDX2

(Negative vs. Positive)

2.135 (0.670–6.805)

0.199

-

-

MMR status

(pMMR vs. dMMR)

3.300 (0.806–13.507)

0.097

-

0.057

Tumor deposits

(Yes vs. No)

1.837 (1.129–2.990)

0.014

1.900 (1.151–3.136)

0.012

Timing of adjuvant therapy

(> 6 weeks vs. ≤ 6 weeks)

2.965 (1.281–6.861)

0.011

0.062

Adjuvant chemotherapy

(3 to 6 months vs. 3 months)

1.073 (0.658–1.751)

0.777

-

-

Variable

DFS

Univariate analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

Sex

(Woman vs. Man)

0.716 (0.498–1.028)

0.070

-

0.075

Age

(≥ 60 vs. < 60)

1.309 (0.930–1.841)

0.122

-

-

Laparoscopic surgery

(Yes vs. No)

0.756 (0.474–1.206)

0.241

-

-

Tumor location

(Left vs. Right)

0.855 (0.588–1.243)

0.411

-

-

No. LNs harvested

(< 12 vs. ≥ 12)

0.770 (0.463–1.282)

0.316

-

-

Histologic grade

(Poorly vs. Well/moderately)

1.469 (1.005–2.148)

0.047

1.642 (1.121–2.406)

0.011

Histological type

(Mucinous or Signet ring cell vs. Adenocarcinoma)

1.378 (0.892–2.130)

0.149

-

-

Lymphovascular Invasion

(Yes vs. No)

1.371 (0.874–2.150)

0.170

-

-

Perineural invasion

(Yes vs. No)

2.218 (1.540–3.195)

P < 0.001

2.177 (1.506–3.146)

P < 0.001

CDX2

(Negative vs. Positive)

1.361 (0.503–3.683)

0.544

-

-

MMR status

(pMMR vs. dMMR)

1.533 (0.750–3.133)

0.242

-

-

Tumor deposits

(Yes vs. No)

1.731 (1.230–2.435)

0.002

1.683 (1.193–2.376)

0.003

Timing of adjuvant therapy

(> 6 weeks vs. ≤ 6 weeks)

1.710 (0.799–3.661)

0.167

Adjuvant chemotherapy

(3 to 6 months vs. 3 months)

1.071 (0.759–1.512)

0.697

-

-