Fig. 3

PD-L1 and TLS in DDRPLS. A PD-L1 expression increases CD8⁺ T cells, Foxp3⁺ Tregs, CD20⁺ B cells, CD68⁺ macrophages, and LAMP3⁺ DCs. B Number or relative gene expression of TLS per sample (left: IHC data; right: RNA-seq data). Each dot denotes the number or relative gene expression of a sample. C TLS increases CD4⁺ T cells, CD8⁺ T cells, CD68⁺ macrophages, and PD-L1⁺ cells in DDRPLS. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. TLS, tertiary lymphatic structure; DDRPLS, dedifferentiated retroperitoneal liposarcoma; DCs, dendritic cells; IHC, immunohistochemistry; and RNA-seq, RNA sequencing