Development and validation of nomogram for predicting early recurrence after radical gastrectomy of gastric cancer

Table 2 Univariate and multivariate analysis of OS in postoperative patients with gastric cancer

Variables	Univariate		Multivariate
Variables	HR	P	HR	95%CI	P
Age
≤ 60	Ref		Ref
> 60	1.416	0.000	1.357	1.099 ~ 1.675	0.005
Tumour length
< 5cm	Ref		Ref
≥ 5cm	1.380	0.001	0.844	0.680 ~ 1.048	0.124
Vascular tumour thrombus
Negative	Ref		Ref
Positive	1.741	0.000	1.572	1.251 ~ 1.697	0.000
Nerve infiltration
Negative	Ref		Ref
Positive	1.475	0.000	1.008	0.788 ~ 1.291	0.948
Serosa infiltration
Negative	Ref		Ref
Positive	2.660	0.000	1.413	0.898 ~ 2.224	0.135
Neoadjuvant chemotherapy
Positive	Ref
Negative	1.062	0.642
Postoperative chemotherapy
Positive	Ref		Ref
Negative	1.659	0.000	2.069	1.629 ~ 2.629	0.000
Differentiation
Medium–High	Ref		Ref
Low-Medium	1.635	0.001	1.215	0.902 ~ 1.638	0.201
Lymph node staging
N0/1/2	Ref		Ref
N3	1.784	0.000	1.409	1.130 ~ 1.756	0.002
pTNM stage^a
I	Ref		Ref
II	2.001	0.010	1.705	0.942 ~ 3.086	0.078
III	2.839	0.000	1.793	0.977 ~ 3.291	0.059
Recurrence mode
Liver	1.458	0.012	1.278	0.938 ~ 1.740	0.120
Abdominal	1.669	0.000	1.573	1.142 ~ 2.006	0.004
Retroperitoneal LN	1.592	0.030	1.022	0.666 ~ 1.570	0.920
Ovary	0.855	0.532	0.739	0.449 ~ 1.218	0.236
Loco-regional	0.938	0.736	0.764	0.520 ~ 1.123	0.170
Else	Ref		Ref
Early recurrence
No	Ref		Ref
Yes	3.447	0.000	3.265	2.535 ~ 4.206	0.000
CA19-9
Normal	Ref		Ref
Abnormal	1.395	0.002	1.240	0.961 ~ 1.601	0.099
CA242
Normal	Ref		Ref
Abnormal	1.365	0.014	0.962	0.708 ~ 1.307	0.803
CA72-4
Normal	Ref		Ref
Abnormal	1.584	0.000	1.165	0.930 ~ 1.459	0.184

^apTNM stage: Pathological tumour, node, metastasis staging system, AJCC 8th. Data from Zhejiang Cancer Hospital. Reference range: CA19-9 > 37U/ml, CA242 > 20U/ml, CA72-4 > 6.7U/ml

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