Table 3 Two-step multivariate analysis for survival using Cox regression analysis on cohort

Step 1

 Age

1.38

0.87, 2.18

0.166

 TRG

1.50

1.14, 1.96

0.003

 Size

1.53

0.94, 2.49

0.089

 Location

1.17

0.90, 1.53

0.243

 Differentiation

1.59

1.12, 2.25

0.010

 Neoadjuvant

1.15

0.94, 1.41

0.168

 ypStage

1.68

1.29, 2.18

 < 0.001

Step 2

 Age

1.26

0.79, 2.00

0.331

 TRG

1.18

0.85, 1.63

0.318

 Size

1.21

0.73, 2.03

0.458

 Location

1.14

0.88, 1.49

0.314

 Differentiation

1.62

1.14, 2.31

0.007

 Neoadjuvant

1.13

0.93, 1.39

0.219

 ypStage

1.26

0.89, 1.78

0.190

 Newstage

1.79

1.26, 2.54

0.001