Table 2 Subgroup analysis of the prognostic value of CRP for OS in patients with ovarian cancer

Total

14

2894

Random

1.23 (1.11–1.37)

 < 0.001

78.4

 < 0.001

Geographical region

 Asia

10

1951

Random

1.52 (1.13–2.05)

0.005

80.0

 < 0.001

 Non-Asia

4

943

Random

1.60 (0.97–2.63)

0.067

69.3

0.020

Sample size

 < 150

7

618

Random

1.95 (1.24–3.06)

0.004

82.3

< 0.001

 ≥ 150

7

2276

Random

1.26 (0.99–1.61)

0.060

63.4

0.018

FIGO stage

 I–IV

10

2302

Random

1.17 (1.05–1.30)

0.004

81.0

< 0.001

 III–IV/IV

4

592

Fixed

1.72 (1.25–2.36)

0.001

0

0.397

Study center

 Single center

12

2164

Random

1.53 (1.17–1.99)

0.002

75.8

< 0.001

 Multicenter

2

730

Random

1.73 (0.59–5.06)

0.321

89.9

0.002

Treatment

 Surgery + chemotherapy

11

2318

Random

1.23 (1.10–1.37)

< 0.001

81.6

< 0.001

 NAC + surgery/chemotherapy/surgery

3

576

Random

1.19 (0.67–2.11)

0.546

57.3

0.096

CRP cutoff value (mg/L)

 < 10

6

1493

Random

1.70 (1.13–2.56)

0.011

63.0

0.019

 ≥ 10

8

1401

Random

1.10 (1.01–1.20)

0.037

76.8

< 0.001

Cutoff determination

 ROC curve

9

2424

Random

1.52 (1.14–2.03)

0.004

76.0

< 0.001

 Median/mean value

2

148

Fixed

0.99 (0.96–1.02)

0.581

0

0.766

 75th percentile

2

168

Fixed

2.03 (1.36–3.04)

0.001

0

0.403

 Literature

1

154

–

1.88 (1.06–3.34)

0.031

–

–

Survival analysis

 Univariate

7

960

Random

1.54 (1.08–2.20)

0.018

75.7

< 0.001

 Multivariate

7

1934

Random

1.53 (1.09–2.15)

0.015

78.1

< 0.001