Table 1 Baseline characteristics of included studies
Study | Year | Country | Sample size | Age (years), median (range) | Study duration | FIGO stage | Study center | Treatment | Cutoff value (mg/L) | Cutoff determination | Survival endpoint | Follow-up (months), median (range) | Survival analysis | NOS score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kodama, J | 1999 | Japan | 120 | 52 (20–85) | 1985–1992 | I–IV | Single center | Surgery + chemotherapy | 50 | 75th percentile | OS | 1–60 | Multivariate | 8 |
Hefler, L. A | 2008 | Austria | 623 | 60.5 | NR | I–IV | Multicenter | Surgery + chemotherapy | 10 | ROC curve | OS | 25.5 | Multivariate | 8 |
Sharma, R | 2008 | Australia | 154 | 63.3 (30–93) | 2003–2006 | III–IV | Single center | Surgery + chemotherapy | 10 | Literature | OS | 21 | Univariate | 8 |
Nakamura, K | 2012 | Japan | 51 | 60.3 (31–83) | 2007–2010 | I–IV | Single center | Surgery + chemotherapy | 16.7 | Mean value | OS, PFS | 1–40 | Univariate | 7 |
Dobrzycka, B | 2013 | Poland | 118 | 57.6 (19–78) | 2003–2007 | I–IV | Single center | Surgery + chemotherapy | 11.19 | ROC curve | OS, PFS | 24.6 (0.8–58.2) | Multivariate | 7 |
Lu, Y | 2015 | China | 107 | 55 (34–79) | 2006–2010 | I–IV | Multicenter | Surgery + chemotherapy | 8 | ROC curve | OS | 1–60 | Univariate | 9 |
Zhang, W. W | 2015 | China | 190 | 50.6 (24–76) | 2000–2012 | I–IV | Single center | Surgery + chemotherapy | 10 | ROC curve | OS, PFS | 43 (2–164) | Univariate | 8 |
Kumar, A | 2017 | USA | 48 | 68.8 | 2002–2009 | III–IV | Single center | Surgery + chemotherapy | 70 | 75th percentile | OS | 1–12 | Univariate | 7 |
Utsumi, F | 2017 | Japan | 77 | 58 | 2003–2012 | IV | Single center | Chemotherapy | 5 | ROC curve | OS | 27.8 (1–188) | Multivariate | 7 |
Li, Y | 2019 | China | 186 | 59.2 | 2008–2013 | I–IV | Single center | Surgery | 6.8 | ROC curve | OS | 45.5 (2–99.1) | Multivariate | 8 |
Yu, W | 2019 | China | 313 | 64.4 | 2010–2017 | III–IV | Single center | NAC + surgery | 7.4 | ROC curve | OS, PFS | 1–80 | Univariate | 7 |
Chen, K | 2020 | China | 328 | 51 | 2014–2019 | I–IV | Single center | Surgery + chemotherapy | 3.5 | ROC curve | OS, PFS | 52 | Multivariate | 8 |
Sahin, H. O | 2020 | Turkey | 97 | 51 (24–84) | 2012–2019 | I–IV | Single center | Surgery + chemotherapy | 16 | Median value | OS | 56 (1–84) | Univariate | 8 |
Komura, N | 2021 | Japan | 308 | < 50 years: 101 ≥ 51 years: 207 | 2007–2016 | I–IV | Single center | Surgery + chemotherapy | 7.6 | ROC curve | PFS | 1–120 | Multivariate | 7 |
Pan, Q | 2023 | China | 482 | 51.5 (16–79) | 2002–2016 | I–IV | Single center | Surgery + chemotherapy | 5.15 | ROC curve | OS, PFS | 49 (3–190) | Multivariate | 7 |