Table 3 Evaluation of publication bias and sensitivity analysis of MTHFR C677T polymorphisms under recessive genetic model
Index | Egger’s regression | Duval and Tweedie’s trim and fill | |||
|---|---|---|---|---|---|
Intercept | p | Original effect size | Studies trimmed | Adjusted effect size | |
G3-4 Hepatotoxicity | -0.936 | 0.407 | 1.88 (1.39, 2.56) | 0 | 1.88 (1.39, 2.56) |
G3-4 Nephrotoxicity | 1.051 | 0.408 | 1.72 (1.10, 2.67) | 0 | 1.72 (1.10, 2.67) |
G3-4 Mucositis | 0.301 | 0.583 | 1.73 (1.31, 2.28) | 0 | 1.73 (1.31, 2.28) |
G3-4 Hematotoxicity | 0.858 | 0.095 | 1.67 (0.95, 2.92) | 0 | 1.67 (0.95, 2.92) |