Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis

Table 2 Meta-analysis results of Correlation between MTHFR C677T Polymorphism and Adverse Reactions of HD-MTX

Indicators	CT/TT vs. CC					TT vs. CT/CC					T vs. C
	No. of studies	No. of patients	OR (95%CI)	Heterogeneity		No. of studies	No. of patients	OR (95%CI)	Heterogeneity		No. of studies	No. of patients	OR (95%CI)	Heterogeneity
	No. of studies	No. of patients	OR (95%CI)	P	I²	No. of studies	No. of patients	OR (95%CI)	P	I²	No. of studies	No. of patients	OR (95%CI)	P	I²
G3-4 Hepatotoxicity	2	97	0.53 (0.18, 1.57)	0.230	30.5%	3	196	1.88 (1.39, 2.56)	0.772	0.0%	2	97	0.64 (0.15, 2.64)	0.078	67.9%
Asian	1	35	1.13 (0.22, 5.67)	-	-	2	148	1.94 (1.41, 2.67)	0.928	0.0%	1	35	1.32 (0.42, 4.15)	-	-
Caucasian	1	62	0.35 (0.13, 0.99)	-	-	1	48	1.23 (0.36, 4.15)	-	-	1	62	0.31 (0.10, 0.96)	-	-
G3-4 Nephrotoxicity	2	247	1.82 (0.70, 4.75)	0.008	85.9%	4	406	1.72 (1.10, 2.67)	0.096	52.8%	1	210	2.26 (1.25, 4.08)	-	-
Asian	2	247	1.82 (0.70, 4.75)	0.008	85.9%	3	358	1.79 (1.00, 3.22)	0.042	68.4%	1	210	2.26 (1.25, 4.08)	-	-
Caucasian	-	-	-	-	-	1	48	1.54 (0.69, 3.43)	-	-	-	-	-	-	-
G3-4 Gastrointestinal toxicity	1	210	3.43 (0.88, 13.32)	-	-	2	249	1.85 (1.34, 2.56)	0.319	0.0%	1	273	2.25 (0.79, 6.40)	-	-
Asian	1	210	3.43 (0.88, 13.32)	-	-	2	249	1.85 (1.34, 2.56)	0.319	0.0%	1	273	2.25 (0.79, 6.40)	-	-
Caucasian	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
G3-4 Mucositis	2	247	1.62 (0.73, 3.60)	0.057	72.5%	4	406	1.73 (1.31, 2.28)	0.839	0.0%	1	273	1.85 (0.92, 3.69)	-	-
Asian	2	247	1.62 (0.73, 3.60)	0.057	72.5%	3	358	1.77 (1.33, 2.35)	0.751	0.0%	1	273	1.85 (0.92, 3.69)	-	-
Caucasian	-	-	-	-	-	1	48	1.33 (0.47, 3.74)	-	-	-	-	-	-	-
G3-4 Hematotoxicity	1	220	2.67 (0.67, 10.59)	-	-	3	367	1.67 (0.95, 2.92)	0.335	8.7%	1	283	2.05 (0.67, 6.27)	-	-
Asian	1	220	2.67 (0.67, 10.59)	-	-	2	319	2.04 (0.70, 5.88)	0.148	52.2%	1	283	2.05 (0.67, 6.27)	-	-
Caucasian	-	-	-	-	-	1	48	1.45 (0.57, 3.71)	-	-	-	-	-	-	-

ISSN: 1477-7819