Table 5 The relationship between HTS classification and the clinical data of all ICC patients

Age ≥ 60 years

74 (50.3)

79 (47.3)

49 (45.0)

0.750

0.687

Male

85 (57.8)

90 (53.9)

59 (54.1)

0.573

0.751

History of hepatitis B infection

73 (49.7)

55 (32.9)

25 (22.9)

20.613

 < 0.001

Hepatolithiasis

13 (8.8)

18 (10.8)

11 (10.1)

0.332

0.847

ALT ≥ 50 U/L

30 (20.4)

32 (19.2)

22 (20.2)

0.086

0.958

AST ≥ 40 U/L

29 (19.7)

47 (28.1)

33 (30.3)

4.454

0.108

Bilirubin ≥ 21 umol/L

19 (12.9)

27 (16.2)

21 (19.3)

1.910

0.385

AFP ≥ 7 ng/mL

45 (30.6)

54 (32.3)

27 (24.8)

1.878

0.391

CEA ≥ 5 ng/mL

42 (28.6)

53 (31.7)

53 (48.6)

12.347

0.002

CA19-9 ≥ 37 U/mL

73 (49.7)

105 (62.9)

93 (85.3)

34.745

 < 0.001

Poorly differentiated tumor

26 (17.7)

47 (28.1)

36 (33.0)

8.514

0.014

Tumor number ≥ 2

18 (12.2)

52 (31.1)

43 (39.4)

26.419

 < 0.001

Tumor size ≥ 5 cm

53 (36.1)

129 (77.2)

100 (91.7)

101.244

 < 0.001

Vascular invasion

35 (23.8)

65 (38.9)

70 (64.2)

42.706

 < 0.001

Perineural invasion

51 (34.7)

69 (41.3)

47 (43.1)

2.249

0.325

Lymph node invasion

35 (23.8)

69 (41.3)

39 (35.8)

10.965

0.004

HALP < 37.1

8 (5.4)

69 (41.3)

103 (94.5)

203.223

 < 0.001

TBS ≥ 6.3

4 (2.7)

102 (61.1)

99 (90.8)

212.104

 < 0.001

PT (s)

12.00(11.50–12.70)

11.90(11.10–13.00)

12.50(11.50–13.60)

3.695

0.026

INR

0.98(0.91–1.04)

0.97(0.89–1.04)

1.00(0.94–1.11)

0.790

0.454

APTT (s)

33.50(28.60–37.60)

31.60(27.90–35.60)

31.70(28.70–37.85)

0.923

0.398

White blood cell count (10^9/L)

5.80(4.87–7.26)

6.72(4.90–8.25)

6.56(5.63–8.30)

3.976

0.019

Neutrophil count (10^9/L)

3.59(2.82–4.50)

4.50(3.20–5.70)

4.63(3.91–6.46)

12.039

 < 0.001

Lymphocyte count (10^9/L)

1.62(1.38–2.09)

1.62(1.17–1.98)

1.21(0.94–1.53)

30.448

 < 0.001

Platelet count (10^9/L)

189.00(146.00–226.00)

206.00(161.00–259.00)

237.00(183.00–280.50)

15.262

 < 0.001

Hemoglobin (g/L)

141.00(130.00–153.00)

130.00(116.00–138.00)

125.00(112.00–137.50)

27.947

 < 0.001

Albumin (g/L)

42.40(38.70–45.60)

41.30(36.80–45.00)

39.20(35.85–43.40)

8.435

 < 0.001