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Table 3 Postoperative pathological examination and prognosis

From: Feasibility of laparoscopic versus open pancreatoduodenectomy following neoadjuvant chemotherapy for borderline resectable pancreatic cancer: a retrospective cohort study

Variable

Number (%)/median (IQR)

Total (n=77)

OPD (n=57)

LPD (n=20)

P value

Postoperative pathological examination

Tumor differentiation

   

0.411

 Poor

29 (37.7)

23 (40.4)

6 (30.0)

 

 Moderate or well

48 (62.3)

34 (59.6)

14 (70.0)

 

Intravascular tumor thrombus, yes

35 (45.5)

29 (50.9)

6 (30.0)

0.107

Perineural invasion, yes

73 (94.8)

55 (96.5)

18 (90.0)

0.276

Adjacent tissue invasion, yes

59 (76.6)

45 (78.9)

14 (70.0)

0.416

Adjacent organ invasion, yes

30 (39.0)

21 (36.8)

9 (45.0)

0.520

Lymph nodes retrieved

22 (15-29)

22 (17-29)

18.5 (13-29)

0.393

Lymph node metastasis, yes

40 (51.9)

31 (54.4)

9 (45.0)

0.470

R1 margin, yes

10 (13.0)

7 (12.3)

3 (15.0)

0.756

AJCC 8th T stage

   

0.013

 1-3

52 (67.5)

34 (59.6)

18 (90.0)

 

 4

25 (32.5)

23 (40.4)

2 (10.0)

 

AJCC 8th TNM stage

   

0.141

 I

25 (32.5)

15 (26.3)

10 (50.0)

 

 II

23 (29.9)

18 (31.6)

5 (25.0)

 

 III

29 (37.7)

24 (42.1)

5 (25.0)

 

Postoperative complication

Postoperative length of stay, days

12 (9-16)

12 (9-17)

12.5 (9-14.5)

0.714

Clavien-Dindo classification

   

0.018

 None

32 (41.6)

19 (33.3)

13 (65.0)

 

 Yes

Grade 1

27 (35.1)

24 (42.1)

3 (15.0)

 

Grade 2

15 (19.5)

11 (19.3)

4 (20.0)

 

Grade ≥ 3

3 (3.9)

3 (5.3)

0 (0.0)

 

POPF

   

0.174

 None

47 (61.0)

32 (56.1)

15 (75.0)

 

 Yes

Biochemical

23 (29.9)

18 (31.6)

5 (25.0)

 

Grade B

6 (7.8)

6 (10.5)

0 (0.0)

 

Grade C

1 (1.3)

1 (1.8)

0 (0.0)

 

Hemorrhage

   

0.177

 None

71 (92.2)

54 (94.7)

17 (85.0)

 

 Yes

Degree

Mild

5 (6.5)

2 (3.5)

3 (15.0)

 

Sever

1 (1.3)

1 (1.8)

0 (0.0)

 

Time

Early

2 (2.6)

1 (1.8)

1 (5.0)

 

Late

4 (5.2)

2 (3.5)

2 (10.0)

 

Bile leakage, yes

3 (3.9)

2 (3.5)

1 (5.0)

1.000

Delayed gastric emptying, yes

1 (1.3)

1 (1.8)

0 (0.0)

1.000

Reoperation, yes

1 (1.3)

1 (1.8)

0 (0.0)

1.000

Death within 90 days, yes

1 (1.3)

1 (1.8)

0 (0.0)

1.000

Patterns of tumor recurrence (n=50)

Time of recurrence

   

0.764

 Early recurrence

21 (42.0)

16 (43.2)

5 (38.5)

 

 Late recurrence

29 (58.0)

21 (56.8)

8 (61.5)

 

Site of recurrence

   

0.356

 Local

15 (30.0)

9 (24.3)

6 (46.2)

 

 Liver

15 (30.0)

12 (32.4)

3 (23.1)

 

 Multiple

20 (40.0)

16 (43.2)

4 (30.8)

 
  1. Abbreviation: IQR interquartile range, OPD open pancreatoduodenectomy, LPD laparoscopic pancreatoduodenectomy, AJCC American Joint Committee on Cancer, POPF postoperative pancreatic fistula
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World Journal of Surgical Oncology

ISSN: 1477-7819

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