Impact of immunohistochemical expression of kinesin family member 18A (Kif18A) and β-catenin in infiltrating breast carcinoma of no special type

Table 2 Comparison between the studied groups (IDC and control normal breast tissue groups) regarding KIF18A immunostaining

KIF18A		Cases (n = 135)		Control normal breast (n = 40)		Test of sig.	P
KIF18A		No.	%	No.	%	Test of sig.	P
Positivity	Negative	1	0.7	0	0.0	χ²=0.298	^MCp=1.000
Positivity	Positive	134	99.3	40	100.0	χ²=0.298	^MCp=1.000
Localization	Cytoplasmic	59	44.0	0	0.0	χ²=119.814^*	<0.001^*
Localization	Nucleocytoplasmic	75	56.0	39	100	χ²=119.814^*	<0.001^*
Percent	Min.–Max.	0.0–95.0		40.0–80.0		U=1260.50^*	<0.001^*
	Mean ± SD.	74.78 ± 14.99		63.0 ± 11.70
	Median (IQR)	80.0 (70.0–85.0)		62.50(52.50–75.0)
Intensity	Mild	9	6.7	9	22.5	χ²=17.851^*	<0.001^*
	Moderate	34	25.4	18	45.0
	Strong	91	67.9	13	32.5
	Mild + moderate	43	32.1	27	67.5	χ²=16.064^*	<0.001^*
	Strong	91	67.9	13	32.5	χ²=16.064^*	<0.001^*
H score	Low (<210)	59	43.7	40	100.0	χ²=39.085^*	<0.001^*
	High (>210)	76	56.3	0	0.0	χ²=39.085^*	<0.001^*
	Min.–Max.	0.0–285.0		65.0–180.0		U=953.50^*	<0.001^*
	Mean ± SD.	197.93 ± 64.80		129.0 ± 35.41
	Median (IQR)	210 (160.0–255.0)		140 (100.0–150.0)

IQR interquartile range, SD standard deviation, U Mann-Whitney test, χ² chi-square test, MC Monte Carlo, p p value for comparing between the studied groups
^*Statistically significant at p ≤ 0.05

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