Fig. 8From: IFIT3 accelerates the progression of head and neck squamous cell carcinoma by targeting PD-L1 to activate PI3K/AKT signaling pathwayIFIT3 promoted tumorigenicity and the metastasis of HNSC in nude mice. A–D Xenograft tumor volume and weight of the xenograft tumors were measured after mice were sacrificed, IFIT3 knockdown suppressed tumor growth (A, C). IFIT3 upregulation enhanced tumor growth (B, D). E IHC analysis of IFT3 and PD-L1 expression in xenograft tumor tissues. F IFIT3 knockdown suppressed numbers of lung metastatic nodules stained with H&E. G. IFIT3 over-expression promoted numbers of lung metastatic nodules stained with H&EBack to article page