Fig. 7

IFIT3 induced EMT and cancer cell stemness through PI3K/AKT pathway by targeting PD-L1 in HNSC. A PD-L1 over-expression dampened IFIT3 silencing suppressed migration by wound-healing assays. Scale bar, 200 μm. B PD-L1 knockdown dampened IFIT3 over-expression induced migration by wound-healing assays. Scale bar, 200 μm. C PD-L1 over-expression reversed IFIT3 silencing suppressed migration and invasion by transwell assays. Scale bar, 200 μm. D PD-L1 knockdown reversed IFIT3 over-expression induced migration and invasion by transwell assays. Scale bar, 200 μm. E and F Targeting PD-L1 attenuated IFIT3 induced EMT and CSCs markers protein expression levels in FaDu and Cal27 cells