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Table 3 Association between lymphovascular invasion and non-SLNs metastasis according to baseline characteristics

From: Lymphovascular invasion is a significant risk factor for non-sentinel nodal metastasis in breast cancer patients with sentinel lymph node (SLN)-positive breast cancer: a cross-sectional study

Sub-group

Lymphovascular invasion

Non-lymphovascular invasion

OR (95%CI)

Mutually adjusted

Total

Metastasis

Total

Metastasis

Crude

ER

 Negative

28

16

19

5

3.7 (1.1, 13.2)

32.9 (2.4, 453.4)

 Positive

116

78

117

27

6.8 (3.8, 12.2)

6.9 (3.6, 13.3)

HER-2

 Negative

105

66

110

22

6.8 (3.7, 12.5)

7.0 (3.5, 14.2)

 Positive

38

28

25

9

5.0 (1.7, 14.8)

11.6 (2.4, 56.3)

Histology grading

 High

7

4

18

5

3.5 (0.6, 21.4)

inf. (0.0, Inf)

 Low

132

85

99

22

6.3 (3.5, 11.5)

6.1 (3.2, 11.6)

Ki-67

 Low

94

61

109

27

5.6 (3.1, 10.3)

5.9 (2.9, 11.8)

 High

50

33

25

5

7.8 (2.5, 24.3)

12.4 (3.1, 49.2)

Number of positive SLN

  > 2

42

34

20

11

3.5 (1.1, 11.2)

2.6 (0.6, 11.9)

  ≤ 2

102

60

116

21

6.5 (3.5, 12.0)

7.8 (3.9, 15.8)

PR

 Negative

44

27

33

7

5.9 (2.1, 16.6)

23.4 (4.2, 129.7)

 Positive

100

67

103

25

6.3 (3.4, 11.7)

6.0 (3.0, 12.0)

Menopause

 No

88

56

75

18

5.5 (2.8, 11.0)

4.9 (2.3, 10.8)

 Yes

56

38

61

14

7.1 (3.1, 16.1)

9.6 (3.5, 26.3)

Tumor size

  ≤ 2 cm

36

20

57

12

4.7 (1.9, 11.7)

3.9 (1.4, 11.4)

  > 2 cm

108

74

79

20

6.4 (3.4, 12.3)

8.9 (4.0, 19.4)

Age group

  ≤ 50 years

65

13

78

54

9.00 (4.15, 19.53)

8.0 (3.2, 19.5)

  > 50 years

71

19

66

40

4.21 (2.05, 8.66)

4.9 (2.1, 11.3)

  1. The non-lymphovascular invasion group was the reference group. Each stratification adjusted for all the factors (age, ER, HER-2, histology grading, Ki-67, number of positive SLN, PR, menopause, and tumor size) except the stratification factor itself