Apoptosis-related factors are relevant to progression of pancreatic neuroendocrine tumors

Amano, Shota; Hirashita, Teijiro; Kawano, Yoko; Nishida, Haruto; Orimoto, Hiroki; Kawamura, Masahiro; Kawasaki, Takahide; Masuda, Takashi; Endo, Yuichi; Ohta, Masayuki; Daa, Tsutomu; Inomata, Masafumi

doi:10.1186/s12957-023-03267-4

World Journal of Surgical Oncology

Table 4 Correlation between the expression of investigated proteins and clinicopathological data

From: Apoptosis-related factors are relevant to progression of pancreatic neuroendocrine tumors

Clinicopathological data, n (%)		GLUT1		SSTR2a		SSTR5		Survivin		XIAP		Caspase3
Clinicopathological data, n (%)	n	Positive	p value	Positive	p value	Positive	p value	Positive	p value	Positive	p value	Positive	p value
Age, years
< 62	18	9 (50.0)	0.908	15 (83.3)	0.077	8 (44.4)	0.495	12 (66.7)	0.055	10 (55.6)	0.155	12 (66.7)	0.068
≥ 62	29	15 (51.7)	0.908	17 (58.6)	0.077	10 (34.5)	0.495	11 (37.9)		10 (34.5)	0.155	26 (89.7)	0.068
Sex
Female	35	21 (60.0)	0.036	23 (65.7)	0.725	12 (34.3)	0.493	19 (54.3)	0.21	14 (40.0)	0.545	29 (82.9)	0.674
Male	12	3 (25.0)	0.036	9 (75.0)	0.725	6 (50.0)	0.493	4 (33.3)	0.21	6 (50.0)	0.545	9 (75.0)	0.674
Functionality
Non-functional	34	17 (50.0)	0.813	21 (61.8)	0.175	13 (38.2)	1	16 (47.1)	0.677	15 (44.1)	0.726	27 (79.4)	1
Functional	13	7 (53.8)	0.813	11 (84.6)	0.175	5 (38.5)	1	7 (53.8)	0.677	5 (38.5)	0.726	11 (84.6)	1
Tumor size, mm
< 21	33	18 (54.5)	0.464	22 (66.7)	1	12 (36.4)	0.675	12 (36.4)	0.008	10 (30.3)	0.009	30 (90.9)	0.013
≥ 21	14	6 (42.9)	0.464	10 (71.4)	1	6 (42.9)	0.675	11 (78.6)	0.008	10 (71.4)	0.009	8 (57.1)	0.013
Vascular invasion
Negative	41	20 (48.8)	0.666	28 (68.3)	1	16 (39.0)	1	20 (48.8)	1	17 (41.5)	1	33 (80.5)	1
Positive	6	4 (66.7)	0.666	4 (66.7)	1	2 (33.3)	1	3 (50.0)	1	3 (50.0)	1	5 (83.3)	1
Extrapancreatic invasion
Negative	42	19 (45.2)	0.05	28 (66.7)	1	17 (40.5)	0.636	21 (50.0)	1	18 (42.9)	1	35 (83.3)	0.24
Positive	5	5 (100)	0.05	4 (80.0)	1	1 (20.0)	0.636	2 (40.0)	1	2 (40.0)	1	3 (60.0)	0.24
T-stage
T1	33	18 (54.5)	0.245	22 (66.7)	0.408	12 (36.4)	0.895	12 (36.4)	0.014	10 (30.3)	0.009	30 (90.9)	0.012
T2	10	3 (30.0)		6 (60.0)		4 (40.0)		7 (70.0)		6 (60.0)		5 (50.0)
T3	4	3 (75.0)		4 (100)		2 (50.0)		4 (100)		4 (100)		3 (75.0)
N-stage
N0	42	21 (50.0)	1	28 (66.7)	1	16 (38.1)	1	21 (50.0)	1	18 (42.9)	1	34 (81.0)	1
N1	5	3 (60.0)	1	4 (80.0)	1	2 (40.0)	1	2 (40.0)	1	2 (40.0)	1	4 (80.0)	1
M-stage
M0	45	22 (48.9)	0.489	30 (66.7)	1	17 (37.8)	1	21 (46.7)	0.234	18 (40.0)	0.176	36 (80.0)	1
M1	2	2 (100)	0.489	2 (100)	1	1 (50.0)	1	2 (100)	0.234	2 (100)	0.176	2 (100)	1
p-Stage
I	31	17 (54.8)	0.279	21 (67.7)	0.889	12 (38.7)	1	12 (38.7)	0.028	10 (32.3)	0.045	28 (90.3)	0.031
II	10	3 (30.0)		6 (60.0)		4 (40.0)		8 (80.0)		7 (70.0)		5 (50.0)
III	4	2 (50.0)		3 (75.0)		1 (25.0)		1 (25.0)		1 (25.0)		3 (75.0)
IV	2	2 (100)		2 (100)		1 (50.0)		2 (100)		2 (100)		2 (100)
Mitoses / 2mm²
< 2	39	17 (43.6)	0.048	26 (66.7)	1	15 (38.5)	1	16 (41.0)	0.023	13 (33.3)	0.007	34 (87.2)	0.033
≥ 2	8	7 (87.5)	0.048	6 (75.0)	1	3 (37.5)	1	7 (87.5)	0.023	7 (87.5)	0.007	4 (50.0)	0.033
Ki-67 proliferation index
< 3%	39	18 (46.2)	0.245	27 (69.2)	0.697	15 (38.5)	1	18 (46.2)	0.461	15 (38.5)	0.258	33 (84.6)	0.167
≧3%	8	6 (75.0)	0.245	5 (62.5)	0.697	3 (37.5)	1	5 (62.5)	0.461	5 (62.5)	0.258	5 (62.5)	0.167
Grade
G1	37	16 (43.2)	0.101	26 (70.3)	0.622	15 (40.5)	0.249	16 (43.2)	0.204	13 (35.1)	0.089	32 (86.5)	0.04
G2	9	7 (77.8)		5 (55.6)		2 (22.2)		6 (66.7)		6 (66.7)		6 (66.7)
G3	1	1 (100)		1 (100)		1 (100)		1 (100)		1 (100)		0 (0)
Recurrence
Negative	41	20 (48.8)	0.666	28 (68.3)	1	17 (41.5)	0.384	19 (46.3)	0.416	16 (39.0)	0.379	33 (80.5)	1
Positive	6	4 (66.7)	0.666	4 (66.7)	1	1 (16.7)	0.384	4 (66.7)	0.416	4 (66.7)	0.379	5 (83.3)	1

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