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Table 1 Baseline characteristics

From: Neoadjuvant pyrotinib plus trastuzumab and chemotherapy for HER2-positive breast cancer: a prospective cohort study

Characteristic

Total, n(%)

Patients, n (%)

Case group (n = 55)

Control group (n = 83)

Median/years

48.5(20–67)

46(20–66)

52(28–67)

Range/years

  < 60 years

128(92.75)

52(94.55)

76(91.57)

  ≥ 60 years

10(7.25)

3(5.45)

7(8.43)

Menopause status

 Premenopausal

83(60.14)

38(69.09)

45(54.22)

 Postmenopausal

55(39.86)

17(30.91)

38(45.78)

ECOG performance status

 0

118(85.51)

47(85.45)

71(85.54)

 1

20(14.49)

8(14.55)

12(14.46)

Primary tumor size

 T1

8(5.80)

3(5.45)

5(6.02)

 T2

86(62.32)

32(58.18)

54(65.06)

 T3

44(31.88)

20(36.36)

24(28.92)

Primary lymph node status

 N0

31(22.46)

13(23.64)

18(21.69)

 N1

44(31.88)

19(34.55)

25(30.12)

 N2

51(36.96)

20(36.36)

31(37.35)

 N3

12(8.70)

3(5.45)

9(10.84)

Clinical stage

 II

62(44.93)

26(47.27)

36(43.37)

 III

76(55.07)

29(52.73)

47(56.63)

Histologic stage

 II

99(71.74)

41(74.55)

58(69.88)

 III

39(28.26)

14(25.45)

25(30.12)

ER

 Positive

63(45.65)

21(38.18)

42(50.60)

 Negative

75(54.35)

34(61.82)

41(49.40)

PR

 Positive

54(39.13)

19(34.55)

35(42.17)

 Negative

84(60.87)

36(65.45)

48(57.83)

AR

 Positive

117(84.78)

47(85.45)

70(84.34)

 Negative

21(15.22)

8(14.55)

13(15.66)

Ki-67 levels

  < 14%

5(3.62)

2(3.64)

3(3.61)

  ≥ 14%

133(96.38)

53(96.36)

80(96.39)

  1. ECOG Eastern Cooperative Oncology Group, TNM tumor, node, metastasis, ER estrogen receptor, PR progesterone receptor, AR androgen receptor. The positive threshold of ER and PR immunohistochemical staining is ≥ 1%