Table 1 Characteristics of the included studies
Study | Design | NOS score | Group | Occlusion time (min) | Type of resection Minor/Major | Sample size | Age | Gender M/F | Child–Pugh A/B | Cirrhosis Y/N | HBV/HCV | Tumor size | Tumor number S/M | AFP (ng/ml) | Differentiation W/Mo/P | Survival (months) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Xia [23] | R | 8 | IPM | 50 (30–98) | 131/93 | 224 | 48 (21–78) | 173/51 | 141/83 | 169/55 | 209/NR | 6.4 (2.8–20.2) | 145/79 | 143(≥ 400) | NR | mDFS for all patients 26.1 |
2013 | NPM | 85/77 | 162 | 57 (18–79) | 119/43 | 101/61 | 128/34 | 149/NR | 5.9 (2.9–21.3) | 122/40 | 93(≥ 400) | NR | ||||
Huang JW [22] | R | 7 | IPM | NR | 374/338 | 712 | 56.1 ± 16.55 | 505/207 | NR | 518/194 | 543/59 | 8.6 ± 7.8 | 513/199 | 8176.3 ± 3211.5 | NR | NR |
2014 | NPM | 329/289 | 618 | 54.2 ± 22.1 | 473/145 | NR | 322/296 | 469/52 | 7.7 ± 5.1 | 433/185 | 6421.2 ± 5641.9 | NR | NR | |||
Huang ZP [21] | R | 9 | IPM | 41.9 ± 12.3 | 0/158 | 158 | 48.5 ± 12.0 | 129/29 | NR | NR | 134/NR | NR | NR | NR | NR | NR |
2014 | NPM | 0/200 | 200 | 50.4 ± 12.6 | 175/25 | NR | NR | 155/NR | NR | NR | NR | NR | NR | |||
Hao [20] | R | 8 | IPM | 31.5 ± 12.5 | 28/50 | 78 | 57.1 | 60/18 | 48/30 | NR | 63/NR | 32 (≤ 5 cm) 46 (> 5 cm) | 47/31 | NR | 51/27 (W + Mo/P) | OS 19.0 ± 4.2 DFS 14.2 ± 4.6 |
2016 | NPM | 25/35 | 60 | 53.6 | 48/12 | 40/20 | NR | 50/NR | 26 (≤ 5 cm) 34 (> 5 cm) | 39/21 | NR | 37/23 | mOS 20.0 ± 3.8 mDFS 18.0 ± 4.8 | |||
Hao [19] | R | 9 | IPM | 27.7 ± 7.3 | 42/71 | 113 | 51.7 | 76/37 | 74/39 | NR | 92 (HBV + HCV) | 40 (≤ 5 cm) 73 (> 5 cm) | 67/46 | NR | 78/35 (W + Mo/P) | mOS 46.3 mDFS 39.4 |
2017 | NPM | 25/27 | 52 | 55 | 37/15 | 35/17 | NR | 43 (HBV + HCV) | 22 (≤ 5 cm) 30 (> 5 cm) | 34/18 | NR | 32/20 | mOS 52.9 mDFS 47.3 | |||
Famularo [18] | R | 8 | IPM | 23 (14–30) | 153/22 | 176 | 65.1 (58.2–72) | 145/21 | 160/15 | 144/32 | NR | 119 (< 5 cm) 56 (≥ 5 cm) | 133/42 | 21 (6–132) | NR | mOS 46.4 mDFS 26.7 |
2018 | NPM | 228/36 | 265 | 67.6 (59.2–73.9) | 199/66 | 248/16 | 214/51 | NR | 199 (< 5 cm) 65 (≥ 5 cm) | 210/54 | 18 (6–177) | NR | mOS 56.5 mDFS 24.9 | |||
Lee | RCT | IPM | 45 (15–87) | 51/37 | 88 | 58.0 (38.0–84.0) | 75/13 | 88/0 | 53/25 | 66/12 | 3.9 (1.0–12.3) | 64/24 | 28.0 (1.0–191,009.0) | 10/73/5 | NR | |
2019 | NPM | 54/34 | 88 | 60.5 (27.0–81.0) | 75/13 | 88/0 | 50/28 | 70/3 | 3.5 (1.0–18.0) | 68/20 | 25.0 (1.0–16,246.0) | 5/78/5 | NR | |||
Wei [16] | R | 9 | IPM | 50 (30–80) | 59/49 | 108 | 51.45 ± 12.45 | 87/21 | 95/11 | 40/68 | 83/NR | NR | NR | 55 (> 40) | NR | NR |
2019 | NPM | 44/30 | 74 | 49.15 ± 11.10 | 63/11 | 65/6 | 26/48 | 64/NR | NR | NR | 36 (> 40) | NR | NR | |||
Galindo [15] | PSM | 9 | IPM | 19.5 (5–78) | 34/12 | 46 | 69 (49–85) | 36/10 | 32/2 | 34/12 | 4/12 | 3.1 (0.6–14) | 38/8 | NR | NR | NR |
2022 | NPM | 36/10 | 46 | 68 (19–86) | 35/11 | 31/3 | 34/12 | 9/15 | 3.0 (0.3–9.5) | 37/9 | NR | NR | NR |